AI Article Synopsis
- A syndromic gastrointestinal pathogen panel (GIP) was introduced to better diagnose gastrointestinal infections in adults, and this study reviewed its effectiveness from May to December 2018.
- Out of 269 patients with positive GIP results, 37% tested positive for C. difficile using traditional methods, while 63% were only detected with PCR, suggesting some results may not indicate true infections.
- The study found no significant differences in mortality or readmission rates between GIP-positive and control patients, indicating that additional PCR testing might not improve clinical outcomes for patients diagnosed with C. difficile.
Article Abstract
Background: A syndromic gastrointestinal pathogen panel (GIP) was implemented in May 2018. All positive (+) GIP and standard-of-care (SOC) C. difficile results were reviewed.
Methods: A single-center audit of adult patients with GIP results was conducted May-December 2018. We reviewed GIP(+)/SOC(+/-) and GIP(-)/SOC(-) tests (control group) for clinical outcomes.
Results: We reviewed 269 GIP(+) patients. Of 119 GIP(+)/SOC(+) patients, 44 (37%) were positive by toxin A/B enzyme immunoassay, and 75 (63%) by PCR only. Thirty-day mortality and re-admission were not significantly different between groups. CDI rates within 6 months were not significantly different between GIP(+)/SOC(-) and controls (p-value = 0.39). Those with initial SOC(+) tests had more true CDI events within 6 months, compared to controls (p-values < 0.001).
Conclusions: Forty percent of patients with GIP(+) C. difficile were (-) by SOC test, suggesting that true CDI was not present. Additional PCR-based testing may not impact outcomes.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2020.115032 | DOI Listing |
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