The possibility of influencing the pituitary through the cerebral ventricle was examined. Synthetic LH-RH was introduced into the third ventricle of male and female rats and after 4 and 8 minutes, the plasma LH and FSH levels were determined by radioimmunoassay. Both in the male female rats, the LH levels were elevated, but FSH levels remained unchanged. The results show that, after intraventricular LH-RH administration, the LH level can be elevated within a few minutes. It is presumed that the non responsiveness of FSH level after LH-RH may support the view on a separate control of release of each of both hormones.
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