AI Article Synopsis
- - The study explores brain network abnormalities in patients with major depressive disorder (MDD) by examining structural covariance networks using imaging techniques.
- - Researchers analyzed high-resolution brain scans from 77 first-episode, drug-naïve MDD patients and 79 healthy subjects, finding significant differences in key brain networks.
- - A notable abnormality was identified in the medial temporal lobe network, which relates to the severity of depressive symptoms, highlighting the hippocampus and parahippocampal gyrus in MDD patients.
Article Abstract
There has been a growing interest in the abnormality of networks across the brain in major depressive disorder (MDD). We aimed to investigate the structural covariance networks in patients with first-episode and drug-naïve MDD using structural imaging. A total of 77 patients with first-episode and drug-naïve MDD and 79 healthy subjects (HS) were recruited, from whom high-resolution T1-weighted images were analysed. Incident component analysis was used to calculate the brain networks based on grey matter volume covariance. There were significant differences in salience network, medial temporal lobe network, default mode network and central executive network between MDD and HS (p < 0.05). Further, the disturbance of medial temporal lobe network was significantly correlated with the severity of depressive symptoms (p < 0.05). In conclusion, we found a novel abnormality in the brain network in the medial temporal lobe primarily involving the hippocampus and parahippocampal gyrus in patients with first-episode and treatment-naïve MDD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pscychresns.2020.111083 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of solution-focused brief therapy versus case management for psychological distress in adolescents and young adults in a community-based youth mental health service in Singapore: protocol for a randomised controlled trial.
BMJ Open
December 2024
North Region and Department of Psychosis, Institute of Mental Health, Singapore.
Introduction: There are insufficient scalable, evidence-based treatments to meet increasing mental health needs of young people. Offering interim, brief interventions for young persons with psychological distress can improve access to care and mitigate adverse effects of long waiting times. This study tests the efficacy of solution-focused brief therapy (SFBT), a strength-based, goal-directed intervention, in adolescents and young adults at a community-based youth mental health service in Singapore.
View Article and Find Full Text PDFExpression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia.
Ann Gen Psychiatry
January 2025
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Schizophrenia is one of the most debilitating mental illnesses affecting any age group. The mechanism and etiology of schizophrenia are extremely complex and multiple signaling pathways recruit genes implicated in the etiology of this disease. While the role of Wnt/β-catenin signaling in this disorder has been verified, the impact of long noncoding RNAs (lncRNAs) associated with this pathway has not been studied in schizophrenia.
View Article and Find Full Text PDFEarly life stress and functional connectivity in antipsychotic-naïve first episode psychosis patients.
Schizophrenia (Heidelb)
January 2025
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Article Synopsis
- The study investigates how childhood trauma affects brain connectivity in patients experiencing their first episode of psychosis compared to healthy controls.
- Higher scores of sexual abuse and emotional neglect from childhood trauma were linked to increased functional connectivity between specific brain regions (like the amygdala and prefrontal cortex) in these patients.
- The findings suggest that different types of childhood trauma have distinct long-term effects on brain function, highlighting the complex relationship between trauma and psychosis.
The role of 15 mA and 77.5 Hz transcranial alternating current stimulation in blood pressure regulation: A post hoc analysis of a randomized controlled trial.
J Affect Disord
January 2025
Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing Psychosomatic Disease Consultation Center, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Beijing, China. Electronic address:
Background: Transcranial alternating current stimulation (tACS) at 77.5 Hz and 15 mA, targeting the forehead and mastoid areas, has proven efficacious in patients with major depressive disorder (MDD) by simultaneously stimulating multiple brain nuclei and regions, many of which are critical for blood pressure regulation. This post hoc analysis aimed to assess the potential blood pressure-lowering effects of 77.
View Article and Find Full Text PDFFirst episode of psychosis in rural Greece: A multi-center study of the Mobile Mental Health Units.
Int J Soc Psychiatry
January 2025
Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Background: Over the last decades the study of schizophrenia-spectrum disorders has been focused on early and comprehensive intervention during the first episode of psychosis (FEP), but studies in rural settings are only rare. In Greece mental healthcare in rural areas is mostly delivered by the locally-based Mobile Mental Health Units (MMHUs).
Aims: The aim of the present study was to address treatment of FEP patients by the MMHUs in rural areas in Greece, focusing on patients with a first episode of schizophrenia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!