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| http://dx.doi.org/10.1093/toxsci/kfaa053 | DOI Listing |
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Exploring the Implementation of Cognitive Screening in First-Episode Psychosis Settings: The CogScreen Implementation Study.
Early Interv Psychiatry
February 2025
Orygen, Parkville, Victoria, Australia.
Aim: Accurate and appropriate cognitive screening can significantly enhance early psychosis care, yet no screening tools have been validated for the early psychosis population and little is known about current screening practices, experiences, or factors that may influence implementation. CogScreen is a hybrid type 1 study aiming to validate two promising screening tools with young people with first episode psychosis (primary aim) and to understand the context for implementing cognitive screening in early psychosis settings (secondary aim). This protocol outlines the implementation study, which aims to explore the current practices, acceptability, feasibility and determinants of cognitive screening in early psychosis settings from the perspective of key stakeholders.
View Article and Find Full Text PDFIntraoperative initial intracranial pressure demonstrates high diagnostic efficacy for postoperative intestinal mucosal barrier dysfunction following severe traumatic brain injury.
World Neurosurg
January 2025
Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address:
Objective: To investigate the risk factors and their diagnostic efficacy for postoperative intestinal mucosal barrier dysfunction (IBD) following severe traumatic brain injury (sTBI).
Methods: There were 140 patients with sTBI enrolled in this study. Univariate and multivariate logistic regression analyses were conducted to assess the relationship between the clinical data and postoperative IBD in sTBI patients and determine the independent risk factors.
Diffusion-weighted arterial spin labeling MRI to investigate mannitol-induced blood brain barrier disruption.
Magn Reson Imaging
January 2025
Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address:
Purpose: Diffusion-weighted arterial spin labeling (DW-ASL) MRI has been proposed to determine the rate of water exchange (K) across the blood brain barrier (BBB). This study aims to further evaluate K MRI by comparing it with standard dynamic contrast-enhanced (DCE) MRI and histology in association with mannitol-induced disruption of the BBB.
Methods: DW-ASL was measured using a multiple b-value MRI protocol in normal rats at three post-labeling delays (N = 19), before and after intra-carotid injection of mannitol to disrupt BBB in one hemisphere (N = 13).
Design, Current States, and Challenges of Nanomaterials in Anti-Neuroinflammation: A Perspective on Alzheimer's Disease.
Ageing Res Rev
January 2025
Department of Alzheimer's Disease Clinical Research Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China; Jinan University, Guangzhou,510000, China; School of Basic Medical Sciences, Shenzhen University, Shenzhen,518060, China. Electronic address:
Alzheimer's disease (AD), an age-related neurodegenerative disease, brings huge damage to the society, to the whole family and even to the patient himself. However, until now, the etiological factor of AD is still unknown and there is no effective treatment for it. Massive deposition of amyloid-beta peptide(Aβ) and hyperphosphorylation of Tau proteins are acknowledged pathological features of AD.
View Article and Find Full Text PDFUse of multi-modal non-contrast MRI to predict functional outcomes after stroke: A study using DP-pCASL, DTI, NODDI, and MAP MRI.
Neuroimage Clin
January 2025
Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, United States. Electronic address:
Purpose: This study aims to assess whether water exchange rate (k), a surrogate for blood-brain barrier (BBB) permeability, is associated with functional outcomes in patients with acute ischemic stroke (AIS).
Methods: We studied 22 AIS patients enrolled from 1/2022 to 4/2024 who underwent multi-modal non-contrast imaging on a 3.0-Tesla scanner, including DP-pCASL, DTI, NODDI and MAP imaging.
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