With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d0cc00523a | DOI Listing |
Publication Analysis
Top Keywords
protein degradation
8
caged ligase
4
ligase ligand
4
ligand protac-mediated
4
protac-mediated protein
4
degradation light
4
light intent
4
intent achieving
4
achieving greater
4
greater spatiotemporal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!