Background: This is a novel work that includes the use of a biosurfactant extract obtained from corn milling industry (named BS-CSW), with antimicrobial activity, as ingredient in formulations to treat acne vulgaris.
Methodology: With this purpose, it was established an incomplete experimental design with 3 independent variables, based on the concentration of non-nano zinc oxide (ZnO) (0-2%), BS-CSW (0-5%) and salicylic acid (0-2%).
Results: This design allowed to obtain a theoretical model that calculates the inhibitory effect on (also named ) for any formulation carried with the ingredients appointed before. It was observed a clear synergetic effect on the inhibition of between ZnO and BS-CSW, in absence of salicylic acid. This fact allowed to reduce the concentration of ZnO, giving more ecofriendly and biocompatible formulations.
Conclusions: It was observed that the biosurfactant extract, in formulations with intermediate concentration of ZnO (1%), possess an inhibitory effect on considerably higher than ZnO alone and similar to ZnO (1%) with salicylic acid (1%). This fact demonstrates the enormous potential of this bioactive extract in antiacne formulations.
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