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| http://dx.doi.org/10.1038/s41392-020-0131-0 | DOI Listing |
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Article Synopsis
- Chromatin structure is crucial for DNA accessibility and gene expression; disrupting it can lead to diseases and cancer.
- H2B variants, which are slightly different from standard H2B histones, have been found to be dysregulated during processes like epithelial to mesenchymal transition and could function as "oncohistones," similar to other histone mutations linked to cancer.
- Research indicates that these H2B variants modify chromatin dynamics and can affect oncogenic gene expression, suggesting they could serve as early cancer biomarkers and potential therapeutic targets.
Genomic factors associated with substance use disorder relapse: A critical review.
Addict Behav Rep
December 2024
College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Article Synopsis
- Genetic and epigenetic factors play a significant role in increasing the risk of relapse in substance use disorders (SUD), but a thorough investigation of these factors is still needed.
- The review examines various genetic polymorphisms and epigenetic changes (like histone modifications and DNA methylation patterns) linked to SUD relapse, focusing on specific genes like DRD2, GABRA2, and COMT.
- Findings suggest that factors such as CpG hypermethylation in certain genes are connected to severe alcohol use disorder and highlight the need for more research to understand these relationships and improve treatment strategies.
Genetic, Epigenetic, and Microenvironmental Drivers of Cholangiocarcinoma.
Am J Pathol
November 2024
Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Article Synopsis
- * Genetic changes, such as mutations in specific genes, vary across different CCA subtypes and populations, while epigenetic changes influence how genes are expressed and how tumors behave.
- * The interplay between CCA cells and their surrounding environment, including other cancer cells and immune cells, creates a supportive area for tumor growth, emphasizing the need to understand these mechanisms for better treatments.
Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer.
Transl Oncol
January 2025
Department of Oncology Surgery, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address:
Extramural venous invasion (EMVI) detected by computed tomography has been identified as an independent risk factor for distant metastasis in patients with advanced gastric cancer (GC). Cancer-associated fibroblasts (CAFs) are critical for remodeling the tumor microenvironment in GCs. Here, we report that MFAP5+ CAFs promote the formation of EMVI imaging in GC.
View Article and Find Full Text PDFEmerging roles of cancer-associated histone mutations in genomic instabilities.
Front Cell Dev Biol
October 2024
Cancer Epigenomics Laboratory, National Institute of Immunology, New Delhi, India.
Article Synopsis
- Epigenetic mechanisms drive the rapid evolution of cancer cells, with a focus on recent findings related to cancer-associated histone mutations that affect DNA methylation and chromatin structure.
- Key oncohistone mutants, such as H3K27M, H3G34R/V, and H3K36M, play significant roles in cellular differentiation, transcription regulation, and genomic stability, which are critical in cancer development.
- Current research emphasizes the importance of these histone mutations in the DNA damage response and their potential implications for chemotherapy and tumor progression, guiding future treatment strategies for cancers with these specific mutations.
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