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Multifactorial Induction of a "Scleroderma-Like Pattern" Without Underlying Connective Tissue Disease: Diagnostic and Therapeutic Implications.
ACR Open Rheumatol
January 2025
Madonna delle Grazie Hospital, Matera, Italy.
A 60-year-old man with a significant 20-year history of smoking, averaging approximately 20 cigarettes per day, presented with type 2 diabetes mellitus, hypercholesterolemia, and hypertension. Over the preceding three months, the patient reported recurrent episodes of acrocyanosis and erythema of the hands that were primarily induced by cold exposure. A capillaroscopy conducted in November 2024 revealed a "scleroderma-like pattern" that was characterized by enlarged capillaries, megacapillaries, and a capillary density of fewer than eight capillaries per millimeter.
View Article and Find Full Text PDFAlterations on Nailfold Videocapillaroscopy in Myelodysplastic Syndrome and Onychomycosis in a Female Smoker: Microvascular Dysfunction Without Connective Tissue Disease.
Int J Rheum Dis
December 2024
Department of Rheumatology of Lucania-UOSD of Rheumatology, "Madonna delle Grazie" Hospital, Matera, Italy.
A 58-year-old female smoker diagnosed with myelodysplastic syndrome (MDS) presented with Raynaud's phenomenon and a "scleroderma-like" pattern on nailfold capillaroscopy. The capillaroscopic abnormalities were observed across all fingers, including those without clinical manifestations of onychomycosis. Over a two-year follow-up, there was no evidence of clinical or serological progression toward a connective tissue disease, particularly systemic sclerosis.
View Article and Find Full Text PDFThe usefulness of nailfold capillaroscopy in scleroderma-spectrum disorders: a single-centre observational study.
Postepy Dermatol Alergol
June 2024
Department of Rheumatology and Systemic Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.
Article Synopsis
- Nail-fold capillaroscopy is a non-invasive technique used to evaluate microcirculation, helping in the diagnosis and treatment monitoring of scleroderma and related diseases.
- A study of 15 patients with scleroderma-spectrum disorders revealed that mixed systemic connective tissue disease and dermatomyositis were common diagnoses, with distinct capillaroscopic patterns linked to each condition.
- The findings showed that a decrease in the number of blood vessels was associated with interstitial lung disease, and patients with systemic connective tissue disease had higher rates of Raynaud's phenomenon and arthritis compared to those with dermatomyositis.
"Scleroderma" and "Scleroderma-like" Capillaroscopic Pattern-Differences and Similarities.
Curr Rheumatol Rev
May 2024
Department of Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Giessen, Germany.
Introduction: The "scleroderma" type capillaroscopic pattern is a reference pattern in rheumatology that is a diagnostic sign for systemic sclerosis (SSc) in an appropriate clinical context and is observed in more than 90% of scleroderma patients. Similar microvascular changes, the so-called "scleroderma-like", have been described albeit in a lower proportion of patients with other rheumatic diseases, such as dermatomyositis (DM), undifferentiated connective tissue diseases (UCTD), systemic lupus erythematosus (SLE), etc. Three distinct stages of "scleroderma" pattern have been suggested by Cutolo .
View Article and Find Full Text PDFGastric dysrhythmias in patients with early systemic sclerosis: a cross-sectional study.
Rheumatol Adv Pract
March 2024
Rheumatology Section, Medicine Department, Hospital Clínico de la Universidad de Chile, Santiago, Chile.
Objectives: Gastric involvement in patients with early systemic sclerosis (SSc) has not been previously investigated. We aim to evaluate the association of gastric dysrhythmias with gastrointestinal (GI) symptoms and nailfold video capillaroscopy (NVC).
Methods: Cross-sectional study.
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