Objective: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends.
Methods: The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models.
Results: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year.
Conclusion: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134554 | PMC |
| http://dx.doi.org/10.6061/clinics/2020/e1507 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of Human Papillomavirus-DNA Test on Salivary Gland Fine Needle Aspiration Cytology Samples Confirms the Absence of the Virus in Primary Neoplasms and Demonstrates for the First Time Its Presence in Salivary Intraglandular Cysts.
Diagn Cytopathol
December 2024
Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Article Synopsis
- The study explored the connection between Human Papillomavirus (HPV) and salivary gland tumors, which remains unclear in existing literature.
- The research involved 66 salivary gland lesions, using fine needle aspiration cytology to detect HPV-DNA, resulting in HPV found in two cysts and three metastatic carcinomas, but none in primary tumors.
- Ultimately, the study concluded that HPV did not play a role in primary salivary gland tumors, but its presence in intraglandular cysts suggests a new area for further investigation.*
PI3K/AKT Immunoexpression Influences the Prognostic Factors of Patients Diagnosed with Oropharyngeal Squamous Cell Carcinoma.
Asian Pac J Cancer Prev
November 2024
Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.
Background: Squamous cell carcinoma (SCC) is the most common histological type in the oropharynx with high incidence and mortality. The Pi3K-AKT signaling pathway is important for understanding prognostic factors such as metastasis, which is involved in the aetiopathogenesis of cancer and is associated with angiogenesis, progression, and cell survival. The aim of this study was to evaluate the correlation of the Pi3K/AKT pathway with prognostic factors associated with oropharyngeal SCC, including overall survival.
View Article and Find Full Text PDFPrevalence of Human Polyomaviruses in Oral and Oropharyngeal Squamous Cell Carcinoma From Patients Treated at a Cancer Center in Sao Paulo, Brazil.
J Med Virol
December 2024
Postgraduate Program in Translational Medicine, Departament of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Article Synopsis
- This study focuses on the presence of human polyomaviruses (HPyV) in head and neck squamous cell carcinoma (SCC) samples, particularly examining the role of these viruses alongside traditional risk factors like smoking and alcohol.
- Researchers analyzed 60 samples from different mouth and throat areas for four types of HPyV, finding a 60% positivity rate for JCPyV and low rates for MCPyV (5%) with no instances of BKPyV or TSPyV.
- The study concluded that while JCPyV is commonly present in oral cavity and oropharyngeal SCC, no strong links to patient demographics or clinical characteristics were found, except for a notable association between JCP
Significance of REV7 Expression in p16-Negative Oropharyngeal Squamous Cell Carcinoma.
Head Neck
November 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Background: REV7 is a multifunctional protein involved in various biological processes, including DNA damage response. REV7 expression in human cancer cells influences sensitivity to DNA-damaging agents, and its high expression level is reportedly associated with a poor prognosis in many carcinomas. However, the significance of REV7 expression in human papillomavirus 16-negative oropharyngeal squamous cell carcinoma (OPSCC) remains unclear.
View Article and Find Full Text PDFInfluence of Immunoexpression of Mismatch Repair Complex Proteins on Disease-Free Survival in Non-Surgically Treated Oropharyngeal Squamous Cell Carcinomas.
Head Neck Pathol
November 2024
Laboratory of Oral Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Article Synopsis
- The study aimed to assess how MMR complex protein expression affects disease-free survival in oropharyngeal squamous cell carcinoma (SCC) patients who were treated non-surgically.
- Data from 85 cases were analyzed, focusing on clinical-pathological information and immunohistochemical markers (MSH2, MSH6, PMS2, MLH1, and p16) to identify correlations with patient outcomes.
- Results showed that loss of MSH2 in p16- tumors led to shorter disease-free survival, while in p16+ tumors, loss of MSH2 was linked to longer survival, indicating that imbalances in MMR proteins play a crucial role in treatment resistance and patient prognosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!