Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependent type I interferon production.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271120 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2020.03.012 | DOI Listing |
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