Background: The advent of mass cytometry has dramatically increased the parameter limit for immunological analysis. New approaches to analysing high parameter cytometry data have been developed to ease analysis of these complex datasets. Many of these methods assign cells into population clusters based on protein expression similarity.
Results: Here we introduce an additional method, termed Brick plots, to visualize these cluster phenotypes in a simplified and intuitive manner. The Brick plot method generates a two-dimensional barcode that displays the phenotype of each cluster in relation to the entire dataset. We show that Brick plots can be used to visualize complex mass cytometry data, both from fundamental research and clinical trials, as well as flow cytometry data.
Conclusion: Brick plots represent a new approach to visualize complex immunological data in an intuitive manner.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158154 | PMC |
| http://dx.doi.org/10.1186/s12859-020-3469-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Study on the Effect of Soft-Hard Material Interface Differences on Crack Deflection in Nacre-Inspired Brick-and-Mortar Structures.
Biomimetics (Basel)
November 2024
School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
Article Synopsis
- Nacre is known for its impressive combination of strength and toughness, which is examined in a study of its "brick-and-mortar" structure.
- The research includes a simplified model to analyze mechanical performance, looking at stress and strain in various components.
- A new method for controlling crack growth based on nacre's toughening mechanisms is presented, with findings indicating that variations in elastic and softening stiffness significantly influence both strength and toughness.
Mechanical evaluation of soil and artisanal bricks for quality masonry product management, Limpopo South Africa.
Sci Rep
June 2024
Department of Earth Sciences, Faculty of Science, Engineering, and Agriculture, Private Bag X5050, Thohoyandou, 0950, Limpopo Province, South Africa.
The selection of raw materials to produce quality artisanal bricks is imperative for sustainable building in rural regions. Artisanal brick-making process often employs traditional kiln to fire brick because it is an affordable, and applicable technology in the rural region. However, there are noticeable cracks, increasing among buildings constructed with artisanal bricks from the rural region in South Africa.
View Article and Find Full Text PDFDrinking brick tea containing high fluoride increases the prevalence of osteoarthritis in Tibetan, China.
Int J Environ Health Res
November 2024
Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Heilongjiang Province, China.
The prevalence of osteoarthritis (OA) in Tibetans is higher than that in Han, while Tibetans have a habit of drinking brick tea with high fluoride. A cross-sectional study was conducted to explore the association between fluoride exposure in drinking brick tea and OA. All subjects were divided into four groups by the quartiles (Q) of tea fluoride (TF) and urine fluoride (UF).
View Article and Find Full Text PDFInvestigation of Mechanical Properties of Ultra-High-Performance Polyethylene-Fiber-Reinforced Recycled-Brick-Aggregate Concrete.
Polymers (Basel)
November 2023
School of Civil Engineering and Transportation, Northeast Forestry University, Harbin 150040, China.
The utilization of ultra-high-molecular-weight polyethylene fibers (UHMWPEFs) to enhance recycled-brick-aggregate concrete represents an efficacious approach for ameliorating the concrete's performance. This investigation addresses the influences of recycled-brick aggregates (RAs) and UHMWPEFs on the concrete's slump, shrinkage, flexural strength, resistance to chloride-ion ingress, and freeze-thaw durability. The mechanisms through which UHMWPEFs ameliorate the performance of the recycled-brick-aggregate concrete were elucidated at both the micro and macroscopic levels.
View Article and Find Full Text PDFDesigning a Clinician-Centered Wearable Data Dashboard (CarePortal): Participatory Design Study.
JMIR Form Res
December 2023
University of Rhode Island, Kingston, RI, United States.
Background: The recent growth of eHealth is unprecedented, especially after the COVID-19 pandemic. Within eHealth, wearable technology is increasingly being adopted because it can offer the remote monitoring of chronic and acute conditions in daily life environments. Wearable technology may be used to monitor and track key indicators of physical and psychological stress in daily life settings, providing helpful information for clinicians.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!