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Phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in older patients with newly diagnosed acute myeloid leukemia.
Front Immunol
March 2025
State Key Laboratory of Experimental Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Introduction: Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.
View Article and Find Full Text PDFInduction of translation-suppressive G3BP1 stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA.
Hlife
January 2025
Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Maryland, USA.
Plasmid DNA transfection is one of the fundamental tools of biomedical research. Here, we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell lines. Their activations were visible by detection of stress granules (SG) and cGAS-DNA condensates (cGC) in the transfected cells in a plasmid DNA dose-dependent manner.
View Article and Find Full Text PDFAltered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes.
Front Physiol
February 2025
Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Introduction: The leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia. Previous studies have shown that T2DM-induced functional remodeling of cardiac vagal postganglionic (CVP) neurons contributes to ventricular arrhythmogenesis. As leptin resistance is common in T2DM patients, and CVP neurons are located in epicardial adipose pads, a tissue that secretes leptin, in this study we aimed to elucidate a correlation between leptin resistance and CVP neuronal dysfunction in T2DM.
View Article and Find Full Text PDFEffectiveness and Safety of Tralokinumab in Atopic Dermatitis: 1-year Results From a Real-world Multicentre Study.
Acta Derm Venereol
March 2025
Department of Dermatology, CHU Saint Etienne, Saint Etienne, France.
Tralokinumab is a monoclonal antibody selectively targeting IL-13, approved for moderate-to-severe atopic dermatitis (AD), for which real-world data are scarce. This prospective, observational, multicentric study aimed to assess the long-term effectiveness and safety of tralokinumab in patients with AD in a real-world setting. Primary outcomes included 50%, 75%, and 90% improvement in Eczema Area and Severity Index score (EASI50, EASI75, EASI90, respectively) and improvements in Dermatology Life Quality Index (DLQI) at 1 year.
View Article and Find Full Text PDFElectrotaxis disrupts patterns of cell-cell interactions of human corneal epithelial cells in vitro.
Biophys J
March 2025
Mathematical Institute, University of Oxford, Oxford, United Kingdom; School of Medicine and Biomedical Sciences, University of Oxford, Oxford, United Kingdom.
Electrotaxis, the process by which eukaryotic cells establish a polarity and move directionally along an electric field, is a well-studied mechanism to steer the migration of cells in vitro and in vivo. While the influence of an electric field on single cells in culture is well-documented, the influence of the electric field on cell-cell interactions has not been well studied. In this work, we quantify the length, duration and number of cell-cell interactions during electrotaxis of human corneal epithelial cells and compare the properties of these interactions with those arising in the absence of an electric field.
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