AI Article Synopsis
- A new compound, a 7-ketone sterol named 5,6-epoxy-3,15-dihydroxy-(22,24)-ergosta-8(14),22-dien-7-one, was discovered from a fungus found in mangroves, alongside five other known sterone derivatives.
- The chemical structures of these compounds were determined using detailed spectroscopic techniques and literature comparisons.
- Among these compounds, one showed weak antibacterial effects (MIC of 28.2 μM) while another exhibited moderate antibacterial activity (MIC of 14.6 μM) against specific bacteria.
Article Abstract
A new ,-unsaturated 7-ketone sterol, 5,6-epoxy-3, 15-dihydroxy-(22,24)-ergosta-8(14),22-dien-7-one (), along with five known sterone derivatives, 5,6-epoxy-3,7-dihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 5,6-epoxy-3,7,9-trihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 3,9,15-trihydroxy-(22,24)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (), 3,15-dihydroxyl-(22,24)-ergosta-5,8(14),22-trien-7-one () and (22,24)-ergosta-4,6,8(14),22-tetraen-3,15-dione () were isolated from the mangrove-derived fungus sp. MGF222. Their structures were established on the basis of extensive spectroscopic data and comparison with the data of literature. Compound showed weak antibacterial activity against with the MIC value of 28.2 (±0.52) μM. Compound exhibited moderate antibacterial activity against with the MIC value of 14.6 (±0.47) μM.
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| http://dx.doi.org/10.1080/14786419.2020.1752210 | DOI Listing |
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One new ,-unsaturated 7-ketone sterol from the mangrove-derived fungus sp.MGF222.
Nat Prod Res
November 2021
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, People's Republic of China.
Article Synopsis
- A new compound, a 7-ketone sterol named 5,6-epoxy-3,15-dihydroxy-(22,24)-ergosta-8(14),22-dien-7-one, was discovered from a fungus found in mangroves, alongside five other known sterone derivatives.
- The chemical structures of these compounds were determined using detailed spectroscopic techniques and literature comparisons.
- Among these compounds, one showed weak antibacterial effects (MIC of 28.2 μM) while another exhibited moderate antibacterial activity (MIC of 14.6 μM) against specific bacteria.
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