AI Article Synopsis
- * New cases of MERS-CoV continue to emerge despite ongoing public health measures; hence, there's a critical need for better understanding of the virus and enhanced strategies for prevention and treatment.
- * The review discusses MERS-CoV proteins, potential strategies to combat outbreaks, and emphasizes the integration of computational biology and virology to develop new peptide therapeutics and improve MERS elimination efforts.
Article Abstract
Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a coronavirus-MERS-CoV-that is associated with high mortality. However, the mechanism by which MERS-CoV infects humans remains unclear. To date, there is no effective vaccine or antibody for human immunity and treatment, other than the safety and tolerability of the fully human polyclonal Immunoglobulin G (IgG) antibody (SAB-301) as a putative therapeutic agent specific for MERS. Although rapid diagnostic and public health measures are currently being implemented, new cases of MERS-CoV infection are still being reported. Therefore, various effective measures should be taken to prevent the serious impact of similar epidemics in the future. Further investigation of the epidemiology and pathogenesis of the virus, as well as the development of effective therapeutic and prophylactic anti-MERS-CoV infections, is necessary. For this purpose, detailed information on MERS-CoV proteins is needed. In this review, we describe the major structural and nonstructural proteins of MERS-CoV and summarize different potential strategies for limiting the outbreak of MERS-CoV. The combination of computational biology and virology can accelerate the advanced design and development of effective peptide therapeutics against MERS-CoV. In summary, this review provides important information about the progress of the elimination of MERS, from prevention to treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104727 | PMC |
| http://dx.doi.org/10.1016/j.eng.2018.11.035 | DOI Listing |
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