AI Article Synopsis
- A new fluorogenic sensor using gelatin-stabilized gold nanoparticles on reduced graphene oxide (rGO/Au) was developed for detecting L-Cysteine (L-Cys) with high sensitivity and selectivity.
- The production of the rGO/Au nanohybrid involved a one-pot hydrothermal method, and it showed weak initial fluorescence which improved significantly in the presence of L-Cys due to the restoration of fluorescence.
- The sensor has a very low detection limit of 0.51 nM for L-Cys and has been tested for bioimaging in cancer live cells, demonstrating excellent compatibility for practical applications.
Article Abstract
A highly sensitive and selective fluorogenic sensing of L-Cysteine (L-Cys) was implemented based on gelatin stabilized gold nanoparticles decorated reduced graphene oxide (rGO/Au) nanohybrid. The rGO/Au nanohybrid was prepared by the one-pot hydrothermal method and well characterized by different physiochemical techniques. The nanohybrid exhibits a weak fluorescence of rGO due to the energy transfer from the rGO to Au NPs. The rGO/Au nanohybrid shows enhanced fluorescence activity due to the restoration of quenched fluorescence of rGO/Au nanohybrid in presence of L-Cys. The rGO/Au nanohybrid exhibits much lower detection limit of 0.51 nM for L-Cys with higher selectivity. The fluorescence sensing mechanism arose from the fluorescence recovery due to the stronger interaction between Au NPs and L-Cys, and consequently, the energy transfer was prevented between rGO and Au NPs. The practicability of rGO/Au sensor was implemented by bioimaging measurements in Colo-205 (colorectal adenocarcinoma) and MKN-45 (gastric carcinoma) cancer live cells with excellent biocompatibility.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127153 | PMC |
| http://dx.doi.org/10.1016/j.snb.2017.12.028 | DOI Listing |
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Article Synopsis
- A new fluorogenic sensor using gelatin-stabilized gold nanoparticles on reduced graphene oxide (rGO/Au) was developed for detecting L-Cysteine (L-Cys) with high sensitivity and selectivity.
- The production of the rGO/Au nanohybrid involved a one-pot hydrothermal method, and it showed weak initial fluorescence which improved significantly in the presence of L-Cys due to the restoration of fluorescence.
- The sensor has a very low detection limit of 0.51 nM for L-Cys and has been tested for bioimaging in cancer live cells, demonstrating excellent compatibility for practical applications.
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