Small world network models have been effective in capturing the variable behaviour of reported case data of the SARS coronavirus outbreak in Hong Kong during 2003. Simulations of these models have previously been realized using informed "guesses" of the proposed model parameters and tested for consistency with the reported data by surrogate analysis. In this paper we attempt to provide statistically rigorous parameter distributions using Approximate Bayesian Computation sampling methods. We find that such sampling schemes are a useful framework for fitting parameters of stochastic small world network models where simulation of the system is straightforward but expressing a likelihood is cumbersome.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126433PMC
http://dx.doi.org/10.1016/j.physa.2009.09.053DOI Listing

Publication Analysis

Top Keywords

small network
12
approximate bayesian
8
network models
8
parameter inference
4
inference small
4
network disease
4
models
4
disease models
4
models approximate
4
bayesian computational
4

Similar Publications

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and optic nerve damage, often associated with elevated intraocular pressure (IOP). Retinoid X receptors (RXRs) are ligand-activated transcription factors crucial for neuroprotection, as they regulate gene expression to promote neuronal survival via several biochemical networks and reduce neuroinflammation. This study investigated the therapeutic potential of 9-cis-13,14-dihydroretinoic acid (9CDHRA), an endogenous retinoid RXR agonist, in mitigating RGC degeneration in a high-IOP-induced experimental model of glaucoma.

View Article and Find Full Text PDF

The modern era demands multifunctional materials to support advanced technologies and tackle complex environmental issues caused by these innovations. Consequently, material hybridization has garnered significant attention as a strategy to design materials with prescribed multifunctional properties. Drawing inspiration from nature, a multi-scale material design approach is proposed to produce 3D-shaped hybrid materials by combining chaotic flows with direct ink writing (ChDIW).

View Article and Find Full Text PDF

Introduction: Laser refractive surgeries are a safe option for low-to-moderate refractive corrections, providing excellent visual outcomes. Over the years, various procedures have been introduced into clinical practice, but the most performed today remain Photorefractive Keratectomy (PRK), Laser Keratomileusis (LASIK), and Small Incision Lenticule Extraction (SMILE). Although laser refractive treatments are considered safe, clinicians have focused on the risk of post-surgical ectasia, a rare but serious complication.

View Article and Find Full Text PDF

Objective: The neglect of occult lymph nodes metastasis (OLNM) is one of the pivotal causes of early non-small cell lung cancer (NSCLC) recurrence after local treatments such as stereotactic body radiotherapy (SBRT) or surgery. This study aimed to develop and validate a computed tomography (CT)-based radiomics and deep learning (DL) fusion model for predicting non-invasive OLNM.

Methods: Patients with radiologically node-negative lung adenocarcinoma from two centers were retrospectively analyzed.

View Article and Find Full Text PDF

Objective: This paper aims to address the need for real-time malaria disease detection that integrates a faster prediction model with a robust underlying network. The study first proposes a 5G network-based healthcare system and then develops an automated malaria detection model capable of providing an accurate diagnosis, particularly in areas with limited diagnostic resources.

Methods: The proposed system leverages a deep learning-based YOLOv5x algorithm to detect malaria parasites in thick and thin blood smear samples.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!