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| http://dx.doi.org/10.1016/S0262-4079(11)62015-0 | DOI Listing |
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A thermoplastic chip for 2D and 3D correlative assays combining screening and high-resolution imaging of immune cell responses.
Cell Rep Methods
January 2025
Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Medicine, Center for Infectious Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden. Electronic address:
We present an easy-to-use, disposable, thermoplastic microwell chip designed to support screening and high-resolution imaging of single-cell behavior in two- and three-dimensional (2D and 3D) cell cultures. We show that the chip has excellent optical properties and provide simple protocols for efficient long-term cell culture of suspension and adherent cells, the latter grown either as monolayers or as hundreds of single, uniformly sized spheroids. We then demonstrate the applicability of the system for single-cell analysis by correlating the dynamic cytotoxic response of single immune cells grown under different metabolic conditions to their intracellular cytolytic load at the end of the assay.
View Article and Find Full Text PDFAtezolizumab, bevacizumab, pemetrexed and platinum for EGFR-mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis.
Clin Transl Med
January 2025
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Background: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) remains a significant hurdle for patients with EGFR-mutated non-small cell lung cancer (NSCLC), particularly those lacking the EGFR. IMpower 150 study demonstrated promising efficacy for a combination of immune-chemotherapy and bevacizumab in patients with EGFR-mutated NSCLC.
Methods: This open-label, single-arm, phase II trial evaluated the efficacy and immune cell profile of the modified regimen combining atezolizumab, bevacizumab (7.
The FcγRIIIA (CD16) L48-H/R polymorphism enhances NK cell-mediated antibody-dependent cellular cytotoxicity by promoting serial killing.
Cancer Immunol Res
December 2024
Fox Chase Cancer Center, Philadelphia, PA, United States.
Article Synopsis
- - Many monoclonal antibody therapies for tumors work by activating natural killer (NK) cells through a receptor called CD16, enhancing the immune response against cancer cells.
- - A specific variant of CD16 called L48-H improves NK cell effectiveness, allowing them to kill tumor cells more efficiently by increasing their binding affinity and speeding up the engagement with the cancer cells.
- - The L48-H variant leads to better communication (or "immunological synapse") between NK cells and tumor cells, resulting in stronger signaling and faster response, making it a promising enhancement for cancer treatments.
Searching for a serial killer on a hospital ward.
Forensic Sci Int
December 2024
Tampere University, Faculty of Social Sciences, Arvo building, Arvo Ylpon katu 34, Tampere, Finland.
Article Synopsis
- The case of Lucy Letby illustrates the difficulty of identifying serial killers in healthcare settings, emphasizing the need for improved statistical methods in legal investigations.
- A nurse was convicted for injecting an infant with insulin, and an analysis of 29 suspicious deaths in a geriatric unit revealed a significant correlation between her night shifts and the incidents.
- While statistical methods can enhance investigative targeting, they must complement thorough investigations to accurately determine the causes of death in suspicious cases.
Serial killer and necrophilia: Report of twenty-five years of treatment and management in a rare case.
J Forensic Sci
November 2024
Section of Criminology and Forensic Psychiatry, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
The authors report a case of a sexual serial killer responsible for four homicides (one homosexual and three prostitutes) over a 12-year period. The perpetrator was diagnosed with a severe personality disorder and necrophilia at the time of the crimes and was declared partially mentally impaired and dangerous to societal security by the Court of Jurisdiction for these crimes. The offender served 22 years in prison, including half of the detention in an OPG (High Security Forensic Psychiatry Hospital) receiving psychiatric treatment.
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