Spiroinonotsuoxotriols A () and B (), two highly rearranged pentacyclic triterpenoids featuring a novel 7(8 → 9)abeo-21,24-cyclo-lanostane skeleton, together with their proposed precursors -, were isolated from the sclerotia of the white-rot fungus . Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction. The biogenetic pathway of and was proposed. Compounds and exhibited potent α-glucosidase inhibitory activity as compared with the positive control acarbose.
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http://dx.doi.org/10.1021/acs.orglett.0c00866 | DOI Listing |
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