As acquiring bigger data becomes easier in experimental brain science, computational and statistical brain science must achieve similar advances to fully capitalize on these data. Tackling these problems will benefit from a more explicit and concerted effort to work together. Specifically, brain science can be further democratized by harnessing the power of community-driven tools, which both are built by and benefit from many different people with different backgrounds and expertise. This perspective can be applied across modalities and scales and enables collaborations across previously siloed communities.
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http://dx.doi.org/10.1146/annurev-neuro-100119-110036 | DOI Listing |
Psychophysiology
January 2025
Department of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Cognitive control deficits and increased intra-subject variability have been well established as core characteristics of attention deficit hyperactivity disorder (ADHD), and there is a growing interest in their expression at the neural level. We aimed to study neural variability in ADHD, as reflected in theta inter-trial phase coherence (ITC) during error processing, a process that involves cognitive control. We examined both traditional event-related potential (ERP) measures of error processing (i.
View Article and Find Full Text PDFiScience
January 2025
Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Development and function of an organism depend on coordinated inter-tissue interaction. How such interactions are maintained during tissue renewal and reorganization remains poorly understood. Here, we find that BEN domain transcription factor LIN-14 is required in epidermis for maintaining the position of motor neurons and muscles during developmental tissue reorganization.
View Article and Find Full Text PDFMol Ther Nucleic Acids
March 2025
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Recent advances in molecular science have significantly enlightened our mechanistic understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we performed a multi-omics analysis using SCA7 mice. Entire brain tissue samples were collected from 12-week-old mice, and RNA sequencing, methylation analysis, and proteomic analysis were performed.
View Article and Find Full Text PDFOpen Mind (Camb)
January 2025
Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Children can manipulate non-symbolic representations of both small quantities of objects (about four or fewer, represented by the parallel individuation system) and large quantities of objects (represented by the analog magnitude system, or AMS). Previous work has shown that children can perform a variety of non-symbolic operations over AMS representations (like summing and solving for an unknown addend), but are not able to perform further operations on the derived solutions of such non-symbolic operations. However, while the computational capacity of AMS has been studied extensively in early childhood, less is known about the computational capacity of the parallel individuation system.
View Article and Find Full Text PDFFront Parasitol
July 2024
Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Neurocysticercosis (NCC) is caused by the invasion of larvae in the central nervous system (CNS) and stands as the predominant cause of epilepsy and other neurological disorders in many developing nations. NCC diagnosis is challenging because it relies on brain imaging exams (CT or MRI), which are poorly available in endemic rural or resource-limited areas. Moreover, some NCC cases cannot be easily detected by imaging, leading to inconclusive results.
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