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Nickel and cobalt are essential elements that become toxic at high concentrations. Little is known about nickel and cobalt toxicity in aquatic animals. This study aimed to investigate acute and chronic toxicity of nickel and cobalt in Japanese flounder (Paralichthys olivaceous), with emphasis on oxidative stress reactions, histopathological changes, and differences in gene expression. The lethal concentration for 50% mortality (LC) in 3 and 8 cm Japanese flounder exposed to nickel for 96 h was found to be 86.2 ± 0.018 and 151.3 ± 0.039 mg/L; for cobalt exposure, LC was 47.5 ± 0.015 and 180.4 ± 0.034 mg/L, respectively. Chronic nickel and cobalt exposure caused different degrees of oxidative enzyme activity changes in gill, liver, and muscle tissues. Erythrocyte deformations were detected after acute or chronic exposure to nickel and cobalt. the nickel and cobalt exposure also caused pathological changes such as spherical swelling over other gill patches, rod-like proliferations in the gill patch epithelial cell layer, and disorder in hepatocyte arrangement, cell swelling, and cytoplasm loosening. RNA-Seq indicated that there were 184 upregulated and 185 downregulated genes in the liver of Japanese flounder exposed to 15 mg/L nickel for 28 d. For cobalt, 920 upregulated and 457 downregulated genes were detected. Among these differentially expressed genes, 162 were shared by both nickel and cobalt exposure. In both nickel and cobalt, pathways including fatty acid elongation, steroid biosynthesis, unsaturated fatty acid biosynthesis, fatty acid metabolism, PPAR signaling, and ferroptosis were significantly enriched. Taken together, these results aided our understanding of the toxicity of nickel and cobalt in aquatic animals.
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http://dx.doi.org/10.1016/j.envpol.2020.114516 | DOI Listing |
Nat Commun
March 2025
State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
The study of the stereochemistry of organic sulfur compounds has been ongoing for over a century, with S-chirogenic pharmacophores playing an essential role in drug discovery within bioscience and medicinal chemistry. Traditionally, the synthesis of sulfinamides featuring stereogenic sulfur(IV) centers involves a complex, multistep process that often depends on chiral auxiliaries or kinetic resolution. Here, we introduce an effective and versatile method for synthesizing diverse classes of S-chirogenic sulfinamides through selective aryl and alkenyl addition to sulfinylamines.
View Article and Find Full Text PDFEnviron Sci Technol
March 2025
GFZ Helmholtz Centre for Geosciences, Telegrafenberg, Potsdam 14473, Germany.
Mine tailings generated from hydrometallurgical processing of nickel-cobalt laterite deposits contain high levels of chromium (Cr), with the hexavalent species being a toxic pollutant and carcinogen. However, the partitioning, speciation, and local bonding environment of Cr in the mine tailings remain largely unknown, hindering our ability to predict its toxicity and long-term behavior. Coupling detailed mineralogical, spectroscopic, and geochemical characterization with sequential extraction of tailings from active and rehabilitated dams, we show that Cr is present in its least toxic form, Cr(III), and largely immobilized by recalcitrant minerals.
View Article and Find Full Text PDFSci Rep
March 2025
School of Public Health, Lanzhou University, Lanzhou, China.
Environmental exposure to heavy metals may adversely affect lung function particularly in the elderly. However, limited data are available directly evaluating the relationship of heavy metal exposures with lung function in Chinese elderly. We aimed to investigate the associations between plasma metals and lung function among Chinese elderly residents.
View Article and Find Full Text PDFJ Inorg Biochem
March 2025
Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.
Pyridine-based alcohols and their metal complexes show unique characteristics, such as redox activity, variable coordination modes, and reactivity towards organic substrates, resulting in multifaceted properties and diverse applications. This review explores the structural properties of these ligands when coordinated to metal ions, particularly focusing on their ability to form mononuclear and polynuclear complexes with transition metals such as copper, manganese, nickel, and cobalt. Moreover, square planar complexes with silver, platinum, palladium, and gold are discussed as well.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2025
Key Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China. Electronic address:
Combining pseudocapacitive materials with carbon materials, such as graphene, is a promising strategy to enhance their performance. In this study, we present a novel and feasible approach involving the alternating electrodeposition of reduced graphene oxide (rGO) and nickel-cobalt layered double hydroxide (NiCo-LDH) onto carbon cloth (CC) current collectors to fabricate binder-free supercapacitor electrodes with a layered LDH/rGO/LDH/rGO/CC architecture. The rGO layers are not only coated on CC substrate to regulate the electrodeposition of LDH nanosheets, but also interposed between the LDH layers to further enhance conductivity and provide buffering effects.
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