6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.

Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus , has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol () and 11-hydroxytolypodiol () were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only reduced thromboxane B and superoxide anion (O) generation from lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.