AI Article Synopsis
- The study focuses on two newly created isoxazole-derived aroylhydrazone ligands and their dinuclear copper(II) complexes, investigating their design, synthesis, and cytotoxic effects.
- The compounds were characterized using various spectroscopic methods, with their molecular structures verified through X-ray crystallography, and their stability in water monitored.
- The ligands and complexes were found to interact with calf thymus DNA, showing greater cytotoxicity in structures with a phenol pendant arm compared to a pyridine arm, particularly against the MDA-MB-231 human breast cancer cell line, with their metal ion interactions proposed as a potential mechanism of action.
Article Abstract
This paper reports the design, synthesis and cytotoxicity studies of two new isoxazole-derived aroylhydrazone ligands and their dinuclear copper(II) complexes. Compounds were fully characterized by various spectroscopic and analytical techniques. The molecular structures of four derivatives were confirmed by X-ray crystallography. The stability of the ligands and the complexes in aqueous medium was monitored spectroscopically. Both the ligands and the complexes were shown to interact with calf thymus DNA (ct-DNA). Additionally, structures containing a phenol pendant arm were significantly more cytotoxic than those carrying a pendant pyridine substituent, reaching sub-micromolar IC values on the triple-negative human breast cancer cell line MDA-MB-231. The metal chelation and transchelation ability of the compounds towards Fe , Fe and Zn ions was explored as a possible mechanism of action of these compounds.
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| http://dx.doi.org/10.1002/cbic.202000122 | DOI Listing |
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