AI Article Synopsis
- The gastrointestinal tract is a major reservoir for carbapenemase-producing bacteria, which can silently colonize patients and increase the risk of infections.
- Eight patients colonized with OXA-48-producing bacteria were treated for three weeks with oral lactitol and probiotics, with stool samples collected to monitor changes.
- Results showed a significant reduction in OXA-48 bacteria, with some patients achieving decolonization, indicating that the treatment was both effective and well-tolerated.
Article Abstract
Background: The major reservoir of carbapenemase-producing (CPE) is the gastrointestinal tract of colonized patients. Colonization is silent and may last for months, but the risk of infection by CPE in colonized patients is significant.
Methods: Eight long-term intestinal carriers of OXA-48-producing (OXA-PE) were treated during 3 weeks with daily oral lactitol (Emportal), and (Infloran). Weekly stool samples were collected during the treatment period and 6 weeks later. The presence of OXA-PE was investigated by microbiological cultures and qPCR.
Results: At the end of treatment (EoT, secondary endpoint 1), four of the subjects had negative OXA-PE cultures. Three weeks later (secondary endpoint 2), six subjects were negative. Six weeks after the EoT (primary endpoint), three subjects had negative OXA-PE cultures. The relative intestinal load of OXA-PE decreased in all the patients during treatment.
Conclusions: The combination of prebiotics and probiotics was well tolerated. A rapid reduction on the OXA-PE intestinal loads was observed. At the EoT, decolonization was achieved in three patients. NCT02307383. EudraCT Number: 2014-000449-65.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137496 | PMC |
| http://dx.doi.org/10.1186/s13099-020-00354-9 | DOI Listing |
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