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Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats.
Colloids Surf B Biointerfaces
April 2025
Department of Ultrasonography, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Hydrogen sulfide (HS) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the HS donor diallyl trisulfide (PM-MSN-DATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content.
View Article and Find Full Text PDFUltrasonographic assessment of ocular parameters in dogs: effects of weight and breed, controlled for BCS and age.
Front Vet Sci
November 2024
Department of Veterinary Medical Imaging, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.
Introduction: Ophthalmic ultrasound is useful tool for examining canine eyes. Previous studies have compared ocular parameters using ophthalmic ultrasonography based on body weight, breed, sex, and age. However, there are limited studies involving large numbers of dogs with controlled body condition score.
View Article and Find Full Text PDFAccelerating thrombolysis of arterial thrombus with NO-MBs UTMD therapy.
Eur J Pharm Biopharm
December 2024
Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China; The Department of Medical Ultrasound, First Affiliated Hospital of Shenzhen University, Second People's Hospital of Shenzhen, Guangdong Province, China. Electronic address:
Article Synopsis
- Arterial thrombotic disease is a significant health issue, and nitric oxide (NO) can help delay thrombosis and tissue damage, but its systemic delivery poses challenges.
- A novel approach using lipid microbubbles filled with NO (NO-MBs) and ultrasound-targeted microbubble destruction (UTMD) allows for targeted, real-time delivery of NO and has shown promising results in accelerating thrombolysis.
- The treatment demonstrated strong biosafety and effectively reduced inflammation and oxidative stress associated with thromboembolism, indicating its potential for treating arterial thrombotic diseases.
Nonmetallic graphite for tumor magnetic hyperthermia therapy.
Biomaterials
April 2024
School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China. Electronic address:
Magnetic hyperthermia therapy (MHT) has garnered immense interest due to its exceptional spatiotemporal specificity, minimal invasiveness and remarkable tissue penetration depth. Nevertheless, the limited magnetothermal heating capability and the potential toxicity of metal ions in magnetic materials based on metallic elements significantly impede the advancement of MHT. Herein, we introduce the concept of nonmetallic materials, with graphite (Gra) as a proof of concept, as a highly efficient and biocompatible option for MHT of tumors in vivo for the first time.
View Article and Find Full Text PDFOne-Minute Preparation of Iron Foam-Drug Implant for Ultralow-Power Magnetic Hyperthermia-Based Combination Therapy of Tumors in Vivo.
Adv Sci (Weinh)
March 2024
School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, China.
The magnetic hyperthermia-based combination therapy (MHCT) is a powerful tumor treatment approach due to its unlimited tissue penetration depth and synergistic therapeutic effect. However, strong magnetic hyperthermia and facile drug loading are incompatible with current MHCT platforms. Herein, an iron foam (IF)-drug implant is established in an ultra-facile and universal way for ultralow-power MHCT of tumors in vivo for the first time.
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