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Genetic inbreeding load and its individual prediction for milk yield in French dairy sheep.
Genet Sel Evol
January 2025
GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
Background: The magnitude of inbreeding depression depends on the recessive burden of the individual, which can be traced back to the hidden (recessive) inbreeding load among ancestors. However, these ancestors carry different alleles at potentially deleterious loci and therefore there is individual variability of this inbreeding load. Estimation of the additive genetic value for inbreeding load is possible using a decomposition of inbreeding in partial inbreeding components due to ancestors.
View Article and Find Full Text PDFPopulation Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRAS Mutation from Phase 1 and Phase 2 Studies.
AAPS J
January 2025
Clinical Pharmacology Modeling and Simulation, Amgen, One Amgen Center Drive, Thousand Oaks, CA, 91320-0777, USA.
Sotorasib is a novel KRAS inhibitor that has shown robust efficacy, safety, and tolerability in patients with KRAS mutation. The objectives of the population pharmacokinetic (PK) analysis were to characterize sotorasib population PK in healthy subjects and patients with advanced solid tumors with KRAS mutation from 6 clinical studies, evaluate the effects of intrinsic and extrinsic factors on PK parameters, and perform simulations to further assess the impact of identified covariates on sotorasib exposures. A two-compartment disposition model with three transit compartments for absorption and time-dependent clearance and bioavailability well described sotorasib PK.
View Article and Find Full Text PDFInvestigating eating architecture and the impact of the precision of recorded eating time: a cross-sectional study.
Am J Clin Nutr
January 2025
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:
Background: The precision of recorded eating times directly affects the estimation of eating architecture i.e. size, timing, and frequency of eating.
View Article and Find Full Text PDFApplication of artificial intelligence for nutrient estimation in surface water bodies of basins with intensive agriculture.
Integr Environ Assess Manag
January 2025
División de Estudios de Posgrado e Investigación, Tecnológico Nacional de México/IT de Culiacán, Culiacán, Sinaloa, México.
Eutrophication is one of the most relevant concerns due to the risk to water supply and food security. Nitrogen and phosphorus chemical species concentrations determined the risk and magnitude of eutrophication. These analyses are even more relevant in basins with intensive agriculture due to agrochemical discharges.
View Article and Find Full Text PDFEstimating the contribution of early and late noise in vision from psychophysical data.
J Vis
January 2025
Neural Information Processing Group, University of Tübingen, Tübingen, Germany.
Human performance in psychophysical detection and discrimination tasks is limited by inner noise. It is unclear to what extent this inner noise arises from early noise (e.g.
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