AI Article Synopsis
- MRSA, a type of "Super Bug," is known for causing various infections, with vancomycin being the main antibiotic for treatment.
- This study focuses on a specific strain, Guangzhou-SauVS2, that shows intermediate resistance to vancomycin, especially in a patient with chronic kidney issues.
- The genome of this strain has over 2.6 million base pairs and contains numerous genes linked to both antibiotic resistance and virulence factors that contribute to its ability to cause disease.
Article Abstract
Methicillin-resistant S. aureus (MRSA) has been considered a potential "Super Bugs", responsible for various infectious diseases. Vancomycin has been the most effective antibitic to treat MRSA originated infections. In this study, we aimed at investigating the genomic features of a vancomycin intermediate-resistance S. aureus strain Guangzhou-SauVS2 isolated from a female patient suffering from chronic renal function failure, emphasizing on its antimicrobial resistance and virulence determinants. The genome has a total length of 2,605,384 bp and the G+C content of 33.21%, with 2,239 predicted genes annotated with GO terms, COG categories, and KEGG pathways. Besides the carriage of vancomycin b-type resistance protein responsible for the vancomycin intermediate-resistance, S. aureus strain Guangzhou-SauVS2 showed resistance to β-lactams, quinolones, macrolide, and tetracycline, due to the acquisition of corresponding antimicrobial resistance genes. In addition, virulence factors including adherence, antiphagocytosis, iron uptake, and toxin were determined, indicating the pathogenesis of the strain.
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| http://dx.doi.org/10.1016/j.micpath.2020.104187 | DOI Listing |
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