The article Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin.
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| http://dx.doi.org/10.1007/s11418-020-01401-0 | DOI Listing |
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Phytochemical characterization and comparative analysis of cycloartane-type triterpenes in Astragalus adsurgens and Astragalus membranaceus.
Planta Med
November 2024
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with tandem mass spectrometry-based method to identify cycloartane-type triterpenes.
View Article and Find Full Text PDFCycloartane-type triterpenoids from Combretum quadrangulare Kurz with PCSK9 secretion inhibitory activities.
Phytochemistry
February 2025
Natural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address:
Nine previously undescribed (1-9) and seven known (10-16) cycloartane-type triterpenoids were isolated and characterized from Combretum quadrangulare Kurz using physicochemical and spectroscopic methods. The absolute configurations of these compounds were determined through modified Mosher's method and quantum chemical calculation of electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Their inhibitory activities against PCSK9 secretion were assessed, and a plausible structure-activity relationship was delineated.
View Article and Find Full Text PDFRevisiting the Cyclocephagenols via : Structural Insights and Configurational Revision.
J Nat Prod
November 2024
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.
Article Synopsis
- - The study discovered a new compound, astracondensatol A, alongside six other known derivatives from the methanol extract of roots, focusing on tetrahydropyran cycloartane-type triterpenoids.
- - Researchers used 1D and 2D-NMR spectroscopy and mass spectrometry to determine the structures of these compounds, uncovering anomalies in carbon shifts that led to a revision of the absolute configurations.
- - X-ray crystallography confirmed the absolute configuration of the new compound, highlighting that previous misassignments at C-24 may have resulted from ambiguous data and publication biases.
Insecticidal Triterpenes in Meliaceae III: Plant Species, Molecules, and Activities in .
Int J Mol Sci
July 2024
State Key Laboratory of Green Pesticide, South China Agricultural University, Guangzhou 510642, China.
Plants of the Meliaceae family have long attracted researchers' interest due to their various insecticidal activities, with triterpenes being the main active ingredients. In this paper, we discuss triterpenoids with insecticidal activity from insecticidal plant species of genera (, , , , , , , , , , , , , , and ) in the family Meliaceae. Among these genera, deserves further research, with twelve species possessing insecticidal activity.
View Article and Find Full Text PDFIsolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant .
J Nat Prod
July 2024
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
The isolation, structure determination, and biological evaluation of constituents from the organic extract of Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, and a 7-keto sterol). Among the new compounds, is the first triterpenoid with a trioxaspiro[4.4]nonane side chain, while - are the first 17-γ-lactone tetranortriterpenoids with four oxygenated functional groups at C-1, -3, -6, and -7.
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