AI Article Synopsis
- The study investigated the incidence of enlarged abdominal lymph nodes in patients with autoimmune liver diseases (AILD) compared to those with viral hepatitis, connective tissue disease (CTD), and healthy individuals.
- Enlarged lymph nodes were found in about 70% of AILD patients, with related increases in certain biochemical markers, indicating a potential link between lymph node size and disease activity.
- The findings suggest that lymph node enlargement could serve as a noninvasive indicator of inflammation in AILD, highlighting its clinical significance.
Article Abstract
Background: The enlargement of lymph nodes is a common clinical sign in connective tissue disease (CTD) and viral hepatitis. In this research, we evaluated the incidence of enlarged lymph nodes in autoimmune liver diseases (AILD). Moreover, we identified the clinical significance of abdominal lymph node enlargement in AILD.
Methods: The characteristics of abdominal lymph nodes, including their morphology and distribution, were assessed by ultrasonography and computed tomography in 125 patients with AILD, 54 with viral hepatitis, 135 with CTD, and 80 healthy controls. The pathological and laboratory results of 106 AILD patients were collected to analyze the association between lymphadenectasis and disease activity.
Results: Enlargement of abdominal lymph nodes was found in 69.6% of patients with AILD, 63% of patients with viral hepatitis, 29.6% of patients with CTD, and 2% of healthy controls. Alkaline phosphatase (ALP), glutamate transpeptidase (GGT), and immunoglobulin M (IgM) levels were significantly increased in AILD patients with lymphadenectasis (LA) in contrast to patients without lymphadenectasis (NLA) ( < 0.05). The pathological characteristics of inflammation, cholestasis, and focal necrosis were more common in the LA group than in the NLA group ( < 0.05). As shown by multivariate logistic regression analysis, interface hepatitis (OR = 3.651, < 0.05), cholestasis (OR = 8.137, < 0.05), and focal necrosis (OR = 5.212, < 0.05) were related to LA.
Conclusions: The percentage of abdominal lymph node enlargement in AILD subjects was significantly higher than that in CTD subjects. Therefore, the enlargement of lymph nodes can represent a noninvasive indicator of histological and biochemical inflammation activity in AILD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115048 | PMC |
| http://dx.doi.org/10.1155/2020/3631625 | DOI Listing |
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