Bioenergetics of the Kinesin-8 Motor Isoform.

Biomolecules

Division of Translational Medicine, Wadsworth Center, NYS Department of Health, Albany, NY 12237, USA.

Published: April 2020

The functional organization of microtubules in eukaryotic cells requires a combination of their inherent dynamic properties, interactions with motor machineries, and interactions with accessory proteins to affect growth, shrinkage, stability, and architecture. In most organisms, the Kinesin-8 family of motors play an integral role in these organizations, well known for their mitotic activities in microtubule (MT) length control and kinetochore interactions. In , the function of Kinesin-8 remains elusive. We present here some biochemical properties and localization data that indicate that this motor (DdKif10) shares some motility properties with other Kinesin-8s but also illustrates differences in microtubule localization and depolymerase action that highlight functional diversity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226124PMC
http://dx.doi.org/10.3390/biom10040563DOI Listing

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