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Joker Sign After Drooling Radioactive Saliva.
Clin Nucl Med
January 2025
From the Department of Nuclear Medicine, Cyclotron Research Center, Molecular Imaging and Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital.
Article Synopsis
- A 28-year-old man received high-dose radioactive iodine therapy after having his thyroid removed due to cancer.
- Two weeks later, he developed a red line on his face, resembling the Joker, which was caused by radiation dermatitis from drooling radioactive saliva while sleeping.
- It's important to educate patients on how to prevent saliva from contacting their skin during and after treatment to avoid skin damage and reduce cancer risk.
In silico optimization of analogs derived pro-adrenomedullin peptide to evaluate antimicrobial potential.
Chem Biol Drug Des
July 2024
S-Inova Biotech, Programa de Pós-Graduação Em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Mato Grosso do Sul, Brazil.
Diverse computational approaches have been widely used to assist in designing antimicrobial peptides with enhanced activities. This tactic has also been used to address the need for new treatment alternatives to combat resistant bacterial infections. Herein, we have designed eight variants from a natural peptide, pro-adrenomedullin N-terminal 20 peptide (PAMP), using an in silico pattern insertion approach, the Joker algorithm.
View Article and Find Full Text PDFAnti-Staphy Peptides Rationally Designed from Cry10Aa Bacterial Protein.
ACS Omega
July 2024
S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia Universidade Católica Dom Bosco, Av. Tamandaré, 6000-Jardim Seminario, Campo Grande, MS 79117-900, Brazil.
Article Synopsis
- Bacterial infections are a major health threat, with antibiotic resistance making treatment particularly difficult, especially for staphylococcal infections.
- Antimicrobial peptides (AMPs) like the Cry10Aa protein show potential as alternatives to traditional antibiotics due to their unique properties and effectiveness against multidrug-resistant bacteria.
- The study developed six peptide variants using the Joker algorithm, revealing that two specific peptides (AMPCry10Aa_1 and AMPCry10Aa_5) effectively killed bacteria within two hours, remained stable in human serum, and showed low toxicity to human cells.
Diagnostic Value of Radiographic Singh Index Compared to Dual-Energy X-Ray Absorptiometry Scan in Diagnosing Osteoporosis: A Systematic Review.
Arch Bone Jt Surg
January 2024
Rheumatic Disease Research Center, Mashhad University of Medical Science Mashhad, Iran.
Objectives: Since various medications can control the rate of fractures and subsequent complications of osteoporosis, the early detection of the disease is crucial. This systematic study aimed to compare the diagnostic accuracy of Singh index (SI) with dual-energy X-ray absorptiometry (DEXA) as a benchmark standard for diagnosing osteoporosis.
Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) were utilized in the current study.
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