Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.
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| http://dx.doi.org/10.1016/j.chom.2020.03.015 | DOI Listing |
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Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite.
Cell Host Microbe
April 2020
Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva 1201, Switzerland.
Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.
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