AI Article Synopsis
- The study aimed to assess how often patients with ulcerative colitis (UC) develop arthropathy after undergoing total colectomy, a surgery considered a final treatment for remission.* -
- An analysis of 219 patients revealed that 18.2% developed arthropathy, with polyarthropathy being the most common type, and certain risk factors included higher disease severity and other extraintestinal manifestations (EIMs).* -
- The findings suggest that about 20% of UC patients who had total colectomy experience arthropathy, with pre-surgery disease activity and EIMs serving as significant risk factors.*
Article Abstract
Objective: Patients with ulcerative colitis (UC) often develop arthropathy. The purpose of this study was to determine the frequency of and risk factors for arthropathy in patients with UC who underwent total colectomy which is the final radical treatment lead to remission.
Methods: Patients who underwent total colectomy from January 2007 to April 2016 were analyzed for the development of arthropathy. The type of arthropathy and risk factors for developing arthropathy were analyzed by clinical and endoscopic severity classification, extraintestinal manifestations (EIMs) and medical treatment.
Results: Total of 219 patients who underwent total colectomy with sufficient medical records were analyzed. Forty-eight cases (21.9%) had EIMs, and 40 cases (18.2%) developed arthropathy (57.0% polyarthropathy; 42.5% peripheral arthropathy). Multivariate analysis showed that severity of Matts classification grade 3 or 4 versus grade 1 or 2 (hazard ratio [HR] 2.31, 95% confidence interval [CI] 1.22-4.36, < .05) and EIMs other than arthropathy (HR 3.29, 95% CI 1.43-7.58, < .05) were risk factors for the development of arthropathy.
Conclusion: This study showed that approximately one fifth of patients with UC who underwent total colectomy developed arthropathy. The risk factors for the development of arthropathy were preoperative endoscopic disease activity and EIMs.
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| http://dx.doi.org/10.1080/14397595.2020.1754323 | DOI Listing |
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