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Non-small cell lung cancer (NSCLC) is characterized by diagnosis at an advanced stage, low rate of operability and poor survival. Therefore, there is a need for a biomarker in NSCLC patients to predict the likely outcome and to accurately stratify the patients in terms of the most appropriate treatment modality. To evaluate prognostic value of pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in NSCLC.
View Article and Find Full Text PDFInvestigation of the effects of mir-219-1 gene variants on the development of disease in non-small cell lung cancer patients.
Afr Health Sci
December 2022
Istanbul University, Istanbul Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.
Background: Various variants of the miR-219-1 gene are one of the first genes associated with NSCLC prognosis in the literature.
Objectives: We aimed to genotype two different variants of the miR-219-1 gene and to investigate to using of the result as a biomarker in the diagnosis and treatment of NSCLC.
Materials And Methods: The patients were chosen according to International NSCLC criteria and genomic DNA was isolated from blood (138 patients and 100 healthy individuals).
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder.
J Clin Neurosci
February 2021
Alanya Alaaddin Keykubat University, Department of Neurology, Antalya/Alanya, Turkey; Istanbul Medipol University, Restorative and Regenerative Medicine Center, Istanbul, Turkey.
Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on multiple levels that goes beyond their conventional effects on neurotransmitters.
Method: The study was approved by the Local Ethics Committee of Istanbul Medipol University (10840098-604.
Characteristics of patients with hypertension in a population with type 2 diabetes mellitus. Results from the Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Hypertension Study).
Prim Care Diabetes
April 2021
Erciyes University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kayseri, Turkey.
Background: The present survey aimed to find out the demographical and clinical characteristics of patients with hypertension in a population with type 2 diabetes mellitus (T2DM) in Turkey.
Methods: Patients with T2DM who were followed-up in tertiary endocrine units for at least last one year were recruited. Demographic, clinical and biochemical data of the patients were collected.
Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study).
Lipids Health Dis
November 2020
Department of Endocrinology and Metabolism, Istanbul University, School of Medicine, Istanbul, Turkey.
Background: Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics of patients attaining these targets were investigated in this study. Furthermore, the reasons for not choosing statins and the physicians' attitudes on the treatment of diabetic dyslipidemia were also examined.
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