Methods for rapid diagnosis of meningitis etiology in adults.

Biomark Med

Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS 66160, USA.

Published: April 2020

Infectious meningitis can be caused by viral, bacterial or fungal pathogens. Despite widely available treatments, many types of infectious meningitis are still associated with significant morbidity and mortality. Delay in diagnosis contributes to poor outcomes. Cerebrospinal fluid cultures have been used traditionally but are time intensive and sensitivity is decreased by empiric treatment prior to culture. More rapid techniques such as the cryptococcal lateral flow assay (IMMY), GeneXpert MTB/Rif Ultra (Cepheid) and FilmArray multiplex-PCR (Biofire) are three examples that have drastically changed meningitis diagnostics. This review will discuss a holistic approach to diagnosing bacterial, mycobacterial, viral and fungal meningitis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248681PMC
http://dx.doi.org/10.2217/bmm-2019-0333DOI Listing

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