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Collagen-based hydrogel derived from amniotic membrane loaded with quercetin accelerates wound healing by improving stereological parameters and reducing inflammation in a diabetic rat model.
Tissue Cell
January 2025
Changchun University of Traditional Chinese Medicine, Changchun 130000, China. Electronic address:
In clinical practice, there is a demand for innovative wound healing methods to tackle full thickness skin injuries, especially in those with diabetes. In this study, we examined if collagen-based hydrogel from amniotic membrane (CHAM) loaded with quercetin could enhance healing in diabetic rats. Sixty diabetic rats were randomly divided into the control group, CHAM group, quercetin group, and CHAM+Quercetin group.
View Article and Find Full Text PDFSeroma under the amniotic membrane following simple limbal epithelial transplantation.
BMJ Case Rep
January 2025
Cornea, Dr Shroff's Charity Eye Hospital, New Delhi, India
A woman in her 50s underwent simple limbal epithelial transplantation (SLET) in the left eye for chemical injury with total limbal stem cell deficiency. A seroma, a hitherto unreported complication of the procedure was noted on the 10th postoperative day. It was associated with an accumulation of inflammatory cells and exudates in the inferior part of the amniotic membrane resembling a hypopyon.
View Article and Find Full Text PDFPlacental Membrane Transplantation: Can It Be A Solution For Tissue Defect Repair In Giant Omphaloceles.
Transplant Proc
January 2025
Department of Perinatology, Istanbul Zeynep Kamil Maternity and Children's Diseases Health Training and Research Center, University of Health Sciences, Istanbul, Turkey. Electronic address:
Objectives: This study aimed to evaluate the effect of placental membrane covering of the omphalocele sac on the healing of giant omphaloceles requiring silo repair that could not be treated primarily.
Methods: This prospective study was performed between October 2021 and October 2023 with the approval of our hospital's ethics committee. All pregnant women diagnosed with prenatal giant omphalocele were informed that their own placenta could be used for omphalocele repair if necessary, and their consent was obtained.
A comparative study of human amniotic membrane, tilapia skin collagen, and Centella asiatica derived gel to treat burn wound in rat model.
Cell Tissue Bank
January 2025
Institute of Tissue Banking and Biomaterial Research, Atomic Energy Research Establishment (AERE), Savar, Dhaka, 1349, Bangladesh.
In the quest for an ideal wound healing material, human amniotic membrane (AM), tilapia skin collagen (TSC), and Centella asiatica (CA) have been studied separately for their healing potential. In this study, we formulated AM, TSC, and CA gel and studied their competency and wound healing efficacy in vivo. Gel was formulated using AM, TSC, CA, Carbopol 934, acrylic acid, glycerine, and triethanolamine and physicochemical properties e.
View Article and Find Full Text PDFAlginate-Based Hydrogels with Amniotic Membrane Stem Cells for Wound Dressing Application.
Stem Cells Cloning
January 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Objective: Chronic wounds are a common clinical problem that necessitate the exploration of novel regenerative therapies. We report a method to investigate the in vitro wound healing capacity of an innovative biomaterial, which is based on amniotic membrane-derived stem cells (AMSCs) embedded in an alginate hydrogel matrix. The aim of this study was to prepare an sodium alginate-based hydrogel, cross-linked calcium chloride (CaCl with the active ingredient AMSC (AMSC/Alg-H) and to evaluate its in vitro effectiveness for wound closure.
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