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http://dx.doi.org/10.3928/0147-7447-19881001-10 | DOI Listing |
Epigenetics Chromatin
January 2025
Clinical Big Data Research Center, Scientific Research Center, Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, People's Republic of China.
Background: Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. This modification forms large chromatin domains, known as Large Organized Chromatin Lysine Domains (LOCKs), which span several hundred kilobases.
Result: In this study, we identify and categorize H3K27me3 LOCKs in 109 normal human samples, distinguishing between long and short LOCKs.
Zh Nevrol Psikhiatr Im S S Korsakova
January 2025
Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia.
Locked-in syndrome is a rare neurological disorder. It is characterized by tetraparesis, paralysis of facial and masticatory muscles, anarthria and pseudobulbar syndrome with possible preservation of vertical movements of the eyeballs and blinking, as well as preservation of consciousness. A serious problem with the «locked-in person» syndrome is the inability of the patient to socialize, which causes him to experience no less suffering than from physical limitations.
View Article and Find Full Text PDFHealth Care Anal
January 2025
Macarthur Clinical School, Western Sydney University, Locked Bag, Penrith, NSW, 1797, Australia.
About one-third of Australians use the services of complementary and alternative medicine (CAM); but debate about the role of CAM in public healthcare is vociferous. Despite this, the mechanisms driving CAM healthcare choices are not well understood, especially in rural Australia. From 2016 to 2018, 2,679 persons from the Goulburn Valley, northern Victoria, were surveyed, 28% (755) of whom reporting visiting CAM practitioners.
View Article and Find Full Text PDFNat Commun
January 2025
Morphing Matter Lab, Human-Computer Interaction Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Compliant mechanisms with reconfigurable degrees of freedom are gaining attention in the development of kinesthetic haptic devices, robotic systems, and mechanical metamaterials. However, available devices exhibit limited programmability and form-customizability, restricting their versatility. To address this gap, we propose a metastructure concept featuring reconfigurable motional freedom and tunable stiffness, adaptable to various form factors and applications.
View Article and Find Full Text PDFMicrosyst Nanoeng
January 2025
Institute of Novel Semiconductors, State Key Laboratory of Crystal Materials, Shandong University, 27 South Shanda Road, Shandong, 250100, P. R. China.
Acoustic frequency combs (AFCs) contain equidistant coherent signals with unconventional possibilities on metrology. Previously, implementation of AFCs on mechanical microresonators with large air damping loss is difficult, which restricted their atmospheric applications. In this work, we explore the potentials of a composite diamond/silicon microcantilever for parametric generation of AFCs in ambient air.
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