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The mechanism of amyloid fibril growth from Φ-value analysis.
Nat Chem
January 2025
Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
Amyloid fibrils are highly stable misfolded protein assemblies that play an important role in several neurodegenerative and systemic diseases. Although structural information of the amyloid state is now abundant, mechanistic details about the misfolding process remain elusive. Inspired by the Φ-value analysis of protein folding, we combined experiments and molecular simulations to resolve amino-acid contacts and determine the structure of the transition-state ensemble-the rate-limiting step-for fibril elongation of PI3K-SH3 amyloid fibrils.
View Article and Find Full Text PDFMolecular Signatures of Aeroallergen Sensitization in Respiratory Allergy: A Comparative Study Across Climate-Matched Populations.
Int J Mol Sci
December 2024
Inmunotek SL Laboratories, 28000 Madrid, Spain.
Climate change is significantly altering the dynamics of airborne allergens, affecting their seasonality, allergenicity, and geographic distribution, which correlates with increasing rates of allergic diseases. This study investigates aeroallergen sensitization among populations from Tenerife, Spain, and Lima, Peru-two regions with similar climates but distinct socio-economic conditions. Our findings reveal that Spanish individuals, particularly those with asthma, demonstrate higher sensitization levels to a broader range of allergens, especially mites, with 85% of participants reacting to at least one mite allergen.
View Article and Find Full Text PDFBenefits of Physical Activity in Children with Cardiac Diseases-A Concise Summary for Pediatricians.
Children (Basel)
November 2024
Department of Pediatrics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
A physically active lifestyle offers multiple benefits, including lowering the risk of cardiovascular disease, lowering body-mass index (BMI), and, last but not least, improving the quality of life. However, there are still disincentives to physical activity in children with heart diseases due to the high protection of parents and the scarcity of data in the literature. The purpose of this paper is to help pediatricians and pediatric cardiologists identify the type of physical activity allowed in children with congenital cardiac malformations, thus minimizing the risk of major adverse effects, such as acute coronary syndrome and sudden cardiac death.
View Article and Find Full Text PDFPutting performance bias to the front-lower side of the hole on steep slopes: Differences in strategies and movements between professional and amateur golfers.
PLoS One
December 2024
Graduate School of Informatics, Nagoya University, Nagoya, Aichi, Japan.
When playing on an sloped golf course, the ball often misses the hole to the front-lower side, which is also referred to as the "amateur side." This can be attributed to the difficulty in perceiving the green slope and choosing the appropriate launch direction and ball speed, especially for amateurs. The study had three main objectives.
View Article and Find Full Text PDFThe assessment of sports performance by grip pressure using flexible piezoresistive pressure sensors in seven sports events.
Sci Rep
December 2024
School of Recreation and Community Sport, Capital University of Physical Education and Sports, Beijing, 100191, China.
Flexible micro-sensors have significant application potential in the field of sports performance evaluation. The aim of this study is to assess sports performance by grip pressure using a MMSS sensor (MXene as the sensitive material and melamine sponge as the substrate, a type of flexible piezoresistive pressure sensor). The grip pressures of expert and amateur players are evaluated in single skills events (golf, billiards, basketball, javelin and shot put) and in skills conversion (badminton and tennis).
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