AI Article Synopsis
- The study examines how accurately adult height can be predicted in children with idiopathic growth hormone deficiency (IGHD) using bone age methods, specifically the Bayley-Pinneau (BP) and Tanner-Whitehouse 2 (TW2) methods.
- Results show that both prediction methods initially underestimate adult height at the start of growth hormone (GH) treatment, but after several years of treatment, they tend to overestimate adult height.
- The findings suggest that adjustments in height predictions are necessary for better accuracy in children with IGHD throughout their treatment journey.
Article Abstract
Background: The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown.
Methods: The near adult height (NAH) of patients with IGHD in the KIGS database was compared retrospectively to adult height prediction calculated by the Bayley-Pinneau (BP) prediction based on bone age by Greulich-Pyle (GP) in 315 children and based on the Tanner-Whitehouse 2 (TW2) method in 121 children. Multiple linear regression analyses adjusted for age at GH start, age at puberty, mean dose and years of of GH treatment, and maximum GH peak in stimulation test were calculated.
Results: The mean underestimation of adult height based on the BP method was at baseline 4.1 ± 0.7 cm in girls and 6.1 ± 0.6 cm in boys, at 1 year of GH treatment 2.5 ± 0.5 cm in girls and 0.9 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 0.4 ± 0.6 cm in girls and 3.8 ± 0.5 cm in boys. The mean underestimation of adult height based on the TW2 method was at baseline 5.3 ± 2.0 cm in girls and 7.9 ± 0.8 cm in boys, at 1 year of GH treatment adult height was overestimated in girls 0.1 ± 0.6 cm in girls and underestimated 4.1 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 3.1 ± 1.5 cm in girls and 3.6 ± 0.8 cm in boys.
Conclusions: Height prediction by BP and TW2 at onset of GH treatment underestimates adult height in prepubertal IGHD children, while in mean 6 years after onset of GH treatment these prediction methods overestimated adult height.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219136 | PMC |
| http://dx.doi.org/10.1530/EC-20-0090 | DOI Listing |
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