Widespread technological advances have propelled human genetics into a "big data" era, in which genome-wide data from extremely large cohorts can be integrated with other "-omics" datasets from humans and model systems. Li et al. (2020) demonstrate the power of applying multiple computational analyses to publicly available data to prioritize the study of genes with novel trait associations.
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http://dx.doi.org/10.1016/j.cmet.2020.03.013 | DOI Listing |
Cell
January 2025
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:
Viruses encode proteins that inhibit host defenses, but sifting through the millions of available viral sequences for immune-modulatory proteins has been so far impractical. Here, we develop a process to systematically screen virus-encoded proteins for inhibitors that physically bind host immune proteins. Focusing on Thoeris and CBASS, bacterial defense systems that are the ancestors of eukaryotic Toll/interleukin-1 receptor (TIR) and cyclic GMP-AMP synthase (cGAS) immunity, we discover seven families of Thoeris and CBASS inhibitors, encompassing thousands of genes widespread in phages.
View Article and Find Full Text PDFSyst Rev
December 2024
Centre for Health Promotion Research, School of Health, Leeds Beckett University, Leeds, UK.
Background: Delivery of health and care services using a combination of remote and/or in-person channels and digital and/or traditional tools (Hybrid Service Delivery, HSD) is increasingly seen as a way of improving quality and affordability, improving access, personalisation and sustainability, and reducing inequalities. Across the voluntary, community and social enterprise sector (VCSE), using a combination of remote and/or in-person channels and digital and/or traditional tools (HSD) has enabled the essential provision of services for people who have learning disabilities and/or autistic (LDA). However, it is unclear how different tools and channels have been used, what worked well or not well, for whom, and in what circumstances.
View Article and Find Full Text PDFIndian J Med Microbiol
December 2024
Hospital Infection Control Department, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China. Electronic address:
BMC Nurs
August 2024
Institute of Health and Well-being, University of Suffolk, Ipswich, UK.
Aims: To synthesise evidence regarding organisational practice environment factors affecting healthcare workforce development, recruitment, and retention in the UK.
Methods/data Sources: A systematic search of PubMed, Web of Science, EMBASE, and PsycINFO yielded ten relevant studies published between 2018 and 2023 and conducted in the UK (the last search was conducted in March 2023). Adhering to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, two independent reviewers conducted screening, sifting, and data extraction, applying the quality assessment tool for risk of bias.
Clin Exp Immunol
October 2024
Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai 200443, China.
Psoriasis is a chronic immune-mediated recurrent skin disease causing systemic damage. Increased angiogenesis has been reported to participate in the progression of psoriasis. However, angiogenesis-related genes (ARGs) in psoriasis have not been systematically elucidated.
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