Systematically Sifting Big Data to Identify Novel Causal Genes for Human Traits.

Cell Metab

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Published: April 2020

Widespread technological advances have propelled human genetics into a "big data" era, in which genome-wide data from extremely large cohorts can be integrated with other "-omics" datasets from humans and model systems. Li et al. (2020) demonstrate the power of applying multiple computational analyses to publicly available data to prioritize the study of genes with novel trait associations.

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http://dx.doi.org/10.1016/j.cmet.2020.03.013DOI Listing

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