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Transthyretin variants impact blood-nerve barrier and neuroinflammation in amyloidotic neuropathy.
Brain
January 2025
Department of Neurology, National Taiwan University Hospital, Taipei, 100225, Taiwan.
Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a neurodegenerative disease caused by mutations in the gene encoding transthyretin (TTR). Despite amyloid deposition being pathognomonic for diagnosis, this pathology in nervous tissues cannot fully account for nerve degeneration, implying additional pathophysiology for neurodegeneration, which, however, has not yet been fully elucidated. In this study, neuroinflammation in ATTRv-PN was investigated by examining nerve morphometry, the blood-nerve barrier, and macrophage infiltration in the sural nerves of ATTRv-PN patients and the sciatic nerves of a complementary mouse system, i.
View Article and Find Full Text PDFSolvent influence on the optical absorption, frontier molecular orbitals, and electronic structure of 1-bromo adamantane.
J Mol Model
January 2025
Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province, Chengdu University of Technology, Chengdu, People's Republic of China.
Context: The study of the influence of solvent on 1-bromo adamantane (BAD) exposes prominent solvatochromatic shifts in the optical absorbance and substantial solvent effects on the electronic structure. This facilitates the molecular probe abilities for the BAD with respect to the surrounding environments such as dielectric constant and polarity. BAD exhibits positive solvatochromism for nonpolar solvents and negative solvatochromatic shifts for polar and aromatic solvents.
View Article and Find Full Text PDFHighly pathogenic avian influenza virus (H5N5) detected in an Atlantic walrus () in the Svalbard Archipelago, Norway, 2023.
Emerg Microbes Infect
January 2025
Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
We present the first documented case of highly pathogenic avian influenza virus (HPAIV) subtype H5N5 in an Atlantic walrus (). The animal was found dead in Svalbard, Norway, in 2023. Sequence analysis revealed the highest genetic similarity with virus isolates from different avian hosts.
View Article and Find Full Text PDFOptimized Photochromic Performance of Spiropyran through Incorporation into Hydrogen-Bonded Organic Frameworks and Applications in Anticounterfeiting and Information Encryption.
ACS Appl Mater Interfaces
January 2025
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Photostimulus-responsive fluorescent materials are promising for anticounterfeiting and UV printing due to rapid response and simple preparation. In this paper, we propose a novel strategy to prepare photostimulus-responsive materials SP@HOF-olefin by integrating the photochromic molecule spiropyran (SP) with postsynthetic modified hydrogen-bonded organic frameworks (HOF-olefin). Compared to SP@HOF, the composites SP@HOF-olefin exhibit enhanced photochromic properties, such as a fast response speed, pronounced color contrast, and exceptional fatigue resistance.
View Article and Find Full Text PDFStructure and Corrosion Resistance of Fe40Al5Cr0.2TiB Alloy After Casting and After Homogenization Annealing.
Materials (Basel)
January 2025
Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland.
This article shows the results of research conducted on the corrosion resistance of the FeAl (Fe40Al5Cr0.2TiB) alloy in two variants: the alloy after casting and after homogenization annealing (1000 °C, 93 h). Analysis of the microstructure of these alloys was conducted on the light microscope, and the phase composition was determined by X-ray diffraction.
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