A Pd(II)-catalyzed C(sp)-H/C(sp)-H coupling/annulation of anilides and α-dicarbonyl compounds for the synthesis of diverse -acyl indoles is described. The reaction is achieved by cascade C-H activation, coupling, and intramolecular cyclization. This protocol provides a variety of indoles with high functional group tolerance and excellent regioselectivity. The utility of this protocol is demonstrated by transforming the synthesized compound into diversely functionalized analogues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.0c00877 | DOI Listing |
Publication Analysis
Top Keywords
palladium-catalyzed direct
4
direct oxidative
4
oxidative c-h
4
c-h activation/annulation
4
activation/annulation regioselective
4
regioselective construction
4
construction -acylindoles
4
-acylindoles pdii-catalyzed
4
pdii-catalyzed csp-h/csp-h
4
csp-h/csp-h coupling/annulation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!