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| http://dx.doi.org/10.2217/fon-2020-0252 | DOI Listing |
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Lesser-Known Cyanotoxins: A Comprehensive Review of Their Health and Environmental Impacts.
Toxins (Basel)
December 2024
Faculty of Medicine and Medical Sciences, University of Balamand, Kalhat, Tripoli P.O. Box 100, Lebanon.
Cyanobacteria, also known as blue-green algae, are a diverse phylum of photosynthetic, Gram-negative bacteria and one of the largest microbial taxa. These organisms produce cyanotoxins, which are secondary metabolites that can have significant impacts on both human health and the environment. While toxins like Microcystins and Cylindrospermopsins are well-documented and have been extensively studied, other cyanotoxins, including those produced by and , remain underexplored.
View Article and Find Full Text PDFNR4A1 and NR4A2 orphan nuclear receptors regulate endothelial-to-hematopoietic transition in mouse hematopoietic stem cell specification.
Development
November 2024
Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Hematopoietic stem cells (HSCs) sustain life-long hematopoiesis and emerge during mid-gestation from hemogenic endothelial progenitors via an endothelial-to-hematopoietic transition (EHT). The full scope of molecular mechanisms governing this process remains unclear. The NR4A subfamily of orphan nuclear receptors act as tumor suppressors in myeloid leukemogenesis and have never been implicated in HSC specification.
View Article and Find Full Text PDFArabic translation and validation of the clinician administered Staden schizophrenia anxiety rating scale (S-SARS).
Heliyon
November 2024
School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon.
Background: Research on anxiety in patients with schizophrenia of Arab origin is surprisingly scarce, particularly given that expressions of both psychotic disorders and anxiety disorders can be largely shaped by cultural factors. This study proposes to complement previous research by exploring the psychometric characteristics of an Arabic translation of the Staden Schizophrenia Anxiety Rating Scale (S-SARS) in chronic, remitted patients diagnosed with schizophrenia. As the Arabic version of the Generalized Anxiety Disorder 7-Item Scale (GAD-7) has not been previously validated in Arabic in patients with schizophrenia, this study had as a secondary aim to investigate the psychometric properties of this scale before its use.
View Article and Find Full Text PDFKnowledge and concern towards endometriosis among Lebanese women: a cross-sectional study.
BMC Womens Health
November 2024
Faculty of Public Health, Lebanese University, Hadath, Lebanon.
Article Synopsis
- - Endometriosis is a widespread disease among women, particularly affecting those in the Middle East, and a lack of knowledge leads to delayed diagnoses and increased complications like infertility.
- - A study conducted with 725 Lebanese women showed that only 25.9% had adequate knowledge about endometriosis, with more than 60% unaware of its symptoms.
- - The results indicate that factors like younger age and higher education correlate with greater awareness, emphasizing the need for medical education and awareness campaigns in Lebanon to improve understanding and prompt treatment.
A Multidisciplinary Consensus-Building Exercise to Define and Prioritize Topics in Supportive Care of Children With Cancer at a Global Level.
Cancer Med
November 2024
Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Introduction: Optimal outcomes during childhood cancer treatment require effective management of toxicities, often called supportive care. A lack of agreement on what comprises supportive care limits the development and provision of comprehensive guidance (for this work, we have defined supportive care as any disease- or treatment-related condition experienced by children with cancer, excluding psychosocial conditions, palliative care, survivorship, or procedural topics). To address this gap, we conducted a consensus-building exercise among global experts to define and prioritize topics for supportive care.
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