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Metronidazole-Associated Peripheral Neuropathy in a Patient With End-Stage Renal Failure.
Cureus
December 2024
Internal Medicine, Eastern Virginia Medical School, Norfolk, USA.
Metronidazole is a broad-spectrum antimicrobial that is associated with 0.16% 100-day incidence rates for peripheral neuropathy. In this report, we present an interesting and rare presentation of peripheral neuropathy secondary to metronidazole use for bacteremia and sepsis in a patient with end-stage renal failure.
View Article and Find Full Text PDFDevelopment of cefepime-induced encephalopathy in a patient with depression and rectal cancer: A case report.
Neuropsychopharmacol Rep
March 2025
National Cancer Center Hospital, Tokyo, Japan.
Article Synopsis
- Cefepime, a fourth-generation antibiotic, can cause neurotoxic side effects like encephalopathy, particularly in patients with compromised blood-brain barriers (BBB) and renal issues.
- A case study of a 79-year-old woman with depression and cancer demonstrated that after receiving cefepime, she developed confusion and other neurological symptoms without apparent brain damage or kidney dysfunction.
- The case suggests that depression and cancer may increase the risk of cefepime-induced encephalopathy, highlighting the need for doctors to monitor such patients closely to avoid misdiagnosis and ensure proper treatment.
Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease.
Clin Kidney J
August 2024
Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Article Synopsis
- The link between chronic kidney disease (CKD) and cognitive function is gaining attention, particularly focusing on the effects of antibacterial agents (ABs) used in CKD patients who are more prone to infections.
- This review highlights how ABs can have direct neurotoxic effects on the central nervous system (CNS) and discusses how these medications can also alter gut microbiota, impacting cognitive symptoms through the brain-gut-kidney axis.
- The findings emphasize the need for careful monitoring of AB therapies in CKD patients to manage adverse drug reactions, particularly antibiotic-associated encephalopathy.
Metronidazole-induced encephalopathy in a patient with spondylodiscitis.
Clin Toxicol (Phila)
September 2024
Serviço de Imagiologia Neurológica, Unidade Local de Saúde Santa Maria, Lisboa, Portugal.
Article Synopsis
- Metronidazole-induced encephalopathy is a rare and serious side effect of a medicine called metronidazole that can affect the brain.
- Doctors think it might have something to do with how it interacts with molecules in the body, but they are not completely sure why it happens.
- A 63-year-old man who took this medicine experienced brain problems, but when doctors recognized the issue and stopped the medicine, he started to feel better quickly.
Unveiling the Neurotoxicity of Metronidazole: A Clinical Conundrum.
Cureus
June 2024
General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Metronidazole, a commonly used antiprotozoal agent, has been linked to neurotoxicity in a few individuals. We present the case of a 61-year-old gentleman diagnosed with a liver abscess, who received a total dose of 64 g of metronidazole over a four-week duration. He subsequently developed slurred speech, numbness, and tingling sensation in both feet.
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