AI Article Synopsis
- - Type 2 diabetes (T2D) negatively affects brain function through issues like glucose toxicity, blood-brain barrier damage, and oxidative stress, leading to problems in memory and cognitive processes.
- - Research using rodent models, particularly mice and rats fed high-fat or high-sugar diets, has helped reveal how T2D contributes to brain dysfunction, especially impacting hippocampal-related tasks.
- - The article summarizes key discoveries about how metabolic syndrome caused by unhealthy diets alters brain energy metabolism, affecting both neurons and supporting glial cells, ultimately leading to a T2D phenotype.
Article Abstract
Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood-brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101159 | PMC |
| http://dx.doi.org/10.3389/fnins.2020.00229 | DOI Listing |
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