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Emerging Alzheimer's disease treatment paradigms: A late-stage clinical trial review.
Alzheimers Dement (N Y)
December 2024
Introduction: Without disease-modifying interventions, Medicare and Medicaid spending on Alzheimer's disease (AD) management is expected to reach 637 billion USD annually by 2050. The recent advent of promising AD therapies after decades of a near-total failure rate in clinical trials suggests that more disease-modifying therapies are on the horizon. In this review, we assess the late-stage pipeline of disease-modifying candidates for AD and offer a novel classification of intervention candidates by treatment paradigms-groups of candidates that share an underlying biological mechanism of action and general disease target.
View Article and Find Full Text PDFA improved group quantum key distribution protocol with multi-party collaboration.
Sci Rep
January 2025
Faculty of Computer and Control Engineering, Qiqihar University, Qiqihar, 161000, China.
The rapid advancement of quantum key distribution technology in recent years has spurred significant innovation within the field. Nevertheless, a crucial yet frequently underexplored challenge involves the comprehensive evaluation of security quantum state modulation. To address this issue, we propose a novel framework for quantum group key distribution.
View Article and Find Full Text PDFMetabolomic interpretation of bacterial and fungal contribution to per- and polyfluoroalkyl substances interface migration in waterlogged paddy fields.
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Key Laboratory of Poyang Lake Watershed Agricultural Resource and Ecology of Ministry of Agriculture and Rural Affairs, College of Land Resource and Environment, Jiangxi Agricultural University, Nanchang, 330045, China. Electronic address:
Per- and polyfluoroalkyl substances (PFAS) are widely distributed in paddy soils, and their multi-phase partitioning in soil fractions was proved to be strongly interact with soil microbial community composition and functions. Despite this, soil bacterial and fungal metabolic molecular effects on PFAS water-soil interface migration in waterlogged paddy fields still remain unclear. This study integrated soil untargeted metabolomics with microbial amplicon sequencing to elucidate soil metabolic modulations of 15 PFAS interface release.
View Article and Find Full Text PDFSpecialists' learning from facilitating group peer telementoring: a qualitative study.
BMC Med Educ
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Department of Communication Studies, Baruch College, City University of New York, New York City, NY, USA.
Background: Group peer telementoring supports interprofessional learning through multi-directional and synchronous engagement where experienced and knowledgeable individuals exchange guidance and support with differently experienced and knowledgeable individuals. A leading example of group peer telementoring among medical specialists and medical generalists is Project Extension for Community Healthcare Outcomes (Project ECHO), a rapidly spreading program with demonstrated learning outcomes among community-based medical generalists. Yet the multi-directional exchanges that characterize group peer telementoring interactions suggest that specialists facilitating sessions may also learn from the group experiences.
View Article and Find Full Text PDFOptimized robust learning framework based on big data for forecasting cardiovascular crises.
Sci Rep
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Computers Engineering and Systems Department, Mansoura University, Mansoura, 35516, Egypt.
Numerous Deep Learning (DL) scenarios have been developed for evolving new healthcare systems that leverage large datasets, distributed computing, and the Internet of Things (IoT). However, the data used in these scenarios tend to be noisy, necessitating the incorporation of robust pre-processing techniques, including data cleaning, preparation, normalization, and addressing imbalances. These steps are crucial for generating a robust dataset for training.
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