Dynamic hydrogels were prepared via an oxidative deamination reaction catalyzed by monoamine oxidase B. Amino-containing polysaccharides (or proteins) and oxidative products (aldehydes) formed the dynamic Schiff base linkages, which endowed the hydrogel with excellent self-healing and multiresponsive properties.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/c7tb01108c | DOI Listing |
Adv Sci (Weinh)
January 2025
Orthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, Changzhou Geriatric hospital, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, P. R. China.
Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk of infection and excessive reactive oxygen species (ROS) during the early stage, and the residual bacteria and delayed Osseo integrated interface in the later stage, which jointly creates a complex and dynamic microenvironment and leads to bone non-union. The melatonin carbon dots (MCDs) possess antibacterial and osteogenesis abilities, greatly simplifying the composition of a multifunctional material. Therefore, a multifunctional hydrogel containing MCDs (GH-MCD) is developed to meet the multi-stage and complex repair needs of infectious bone injury in this study.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, China.
Osteoarthritis (OA) is increasingly recognized as a whole-organ disease predominantly affecting the elderly, characterized by typical alterations in subchondral bone and cartilage, along with recurrent synovial inflammation. Despite the availability of various therapeutics and medications, a complete resolution of OA remains elusive. In this study, novel functional hydrogels are developed by integrating natural bioactive molecules for OA treatment.
View Article and Find Full Text PDFMacromol Rapid Commun
January 2025
Department of Biological and Bioenergy Chemical Engineering, College of Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, China.
Cephalopods such as squids, octopuses, and cuttlefishes can change their bodies' color to match the surrounding environments by contracting or expanding the sac just below the surface of the skin. Inspired by this mechanism, artificial cephalopod chromatophores which are prepared by thermoresponsive poly(N-isopropyl acrylamide)-based hydrogel films embedded with black, red, and yellow pigments are presented, they can swell and shrink under temperature stimuli, like the natural chromatophores. The artificial chromatophores embedded with cuttlefish ink are further used to fabricate artificial J.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Mechanical Engineering, Jiangsu University, No.301 Xuefu Road, Zhenjiang 212013, Jiangsu Province, China. Electronic address:
Hydrogel-based bioelectronic systems offer significant benefits for point-of-care diagnosis, treatment of cardiac and cerebral disease, surgical procedures, and other medical applications, ushering in a new era of advancements in medical technology. Progress in hydrogel-based bioelectronics has advanced from basic instrument and sensing capabilities to sophisticated multimodal perceptions and feedback systems. Addressing challenges related to immune responses and inflammation regulation after implantation, physiological dynamic mechanism, biological toxicology as well as device size, power consumption, stability, and signal conversion is crucial for the practical implementation of hydrogel-based bioelectronics in medical implants.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!