Upconversion nanoparticles (UCNPs) have been used as building blocks in the construction of multimodal contrast agents for theranostics, that is, the combination of diagnostics and therapies. Upconversion luminescence (UCL) imaging is widely used for cell and tissue imaging while magnetic resonance imaging (MRI) is well-suited for in vivo imaging. Photothermal therapy (PTT) using (near-infrared) NIR laser radiation constitutes a minimally invasive alternative to the conventional surgical treatment of cancer. As such, multifunctional Mn-complex modified NaDyF:Yb@NaLuF:Yb,Er@polydopamine (PDA) nanocomposites (Dy@Lu@PDA-Mn) were synthesized, which was based on the fact that Yb and Er induce UCL, Dy and Mn interferes with T and T in MRI, and PDA strongly absorbs in the NIR region for PTT. Through tri-modal UCL, T-, T-weighted MRI guiding, an outstanding photothermal therapeutic efficacy with tumour elimination was obtained in a mice breast cancer model, by injection of Dy@Lu@PDA-Mn upon laser irradiation. A strategy for multimodal imaging-guided PTT was formulated and the potential of multifunctional nanostructures for use in cancer theranostics was demonstrated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5tb02785c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis, characterization and superoxide dismutase activity of a biomimetic Mn(III) complex covalently anchored to mesoporous silica.
J Inorg Biochem
December 2022
IQUIR (Instituto de Química Rosario), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. Electronic address:
A mononuclear Mn(III) complex of a clickable ligand, [Mn(hbpapn)(HO)]ClO·4.5HO, where Hhbpapn = 1,3-bis[(2-hydroxybenzyl)(propargyl)amino]propane, has been prepared and fully characterized. The complex catalyzes the dismutation of superoxide employing a Mn(III)/Mn(IV) redox cycle, with catalytic rate constant of 3.
View Article and Find Full Text PDFWell-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols.
J Org Chem
March 2022
Department of Chemistry, Indian Institute of Technology-Guwahati, Kamrup, Assam 781039, India.
Herein, we demonstrated Mn-catalyzed selective C-3 functionalization of indoles with alcohols. The developed catalyst can also furnish bis(indolyl)methanes from the same set of substrates under slightly modified reaction conditions. Mechanistic studies reveal that the C-3 functionalization of indoles is going via a borrowing hydrogen pathway.
View Article and Find Full Text PDFImproved Electrical Wiring of Glucose Oxidase Enzyme with an Immobilized Mn(1,10-Phenanthroline)Cl-Complex/Multiwalled Carbon Nanotube-Modified Electrode Displaying Superior Performance to Os-Complex for High-Current Sensitivity Bioelectrocatalytic and Biofuel Cell Applications.
ACS Appl Bio Mater
November 2018
Nano and Bioelectrochemistry Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology University, Vellore-632 014, India.
The search for a new and efficient transducer that can electrically connect enzyme active sites, like flavin adenine dinucleotide in glucose oxidase (GOx), with the electrode surface is a cutting-edge research area. Currently, Os(bpy)-complex pendent polyvinylpyridine/polyvinyl imidazole/pyridinium hydrogel based chemically modified electrodes have been widely used for this purpose (bpy = 2,2'-bipyridine). Herein, we report, a [Mn(phen)(O)(Cl)] complex/Nafion-immobilized carboxylic acid-functionalized multiwalled carbon nanotube modified glassy carbon electrode (GCE/f-MWCNT@Mn(Phen)O(Cl)-Nf, phen = 1,10-phenanthroline), prepared by an electrochemical method using the precursor, Mn(phen)Cl, as an efficient and low cost alternate to the Os-complex transducer, for the glucose oxidase enzyme (GOx) based bio-electro-catalytic system.
View Article and Find Full Text PDFMn-complex modified NaDyF:Yb@NaLuF:Yb,Er@polydopamine core-shell nanocomposites for multifunctional imaging-guided photothermal therapy.
J Mater Chem B
April 2016
Department of Chemistry, Capital Normal University, Beijing, 100048, P. R. China.
Upconversion nanoparticles (UCNPs) have been used as building blocks in the construction of multimodal contrast agents for theranostics, that is, the combination of diagnostics and therapies. Upconversion luminescence (UCL) imaging is widely used for cell and tissue imaging while magnetic resonance imaging (MRI) is well-suited for in vivo imaging. Photothermal therapy (PTT) using (near-infrared) NIR laser radiation constitutes a minimally invasive alternative to the conventional surgical treatment of cancer.
View Article and Find Full Text PDFBinding properties of 2-acetylnaphthalene with hydroxypropyl cyclodextrins from fluorescence quenching experiments.
Appl Spectrosc
May 2005
Department of Chemistry, Union College, Schenectady, New York 12308, USA.
The quenching of 2-acetylnaphthalene (2-AN) fluorescence by hydroxypropyl cyclodextrins (HP-CD) has been analyzed using modified Stern-Volmer plots to obtain binding constants as a function of temperature for 2-AN:HP-CD complexes. The HP-CDs were commercially available and contained 4-7 HP groups per CD molecule for alpha-CD, beta-CD, and gamma-CD. HP substitution causes a 12 to over 40% increase in binding constant (K(ave)) for 2-AN compared to that for unsubstituted CDs, although the K(ave) value is not strongly dependent on the extent of HP substitution for beta-CD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!