Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(ii) complex-photosensitizer, the polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to two-photon excitation of the Ru(ii)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5tb02726h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Three-dimensional, multi-functionalized nanocellulose/alginate hydrogel for efficient and selective phosphate scavenging: Optimization, performance, and in-depth mechanisms.
Int J Biol Macromol
December 2024
Guangdong-Hong Kong Joint Laboratory for Water Security, Beijing Normal University, Zhuhai 519087, China; Center for Water Research, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai 519087, China. Electronic address:
Challenges in developing adsorbents with sufficient phosphate (P) adsorption capacity, selectivity, and regeneration properties remain to be addressed. Herein, a multi-functionalized high-capacity nanocellulose/alginate hydrogel (La-NCF/SA-PEI [La: lanthanum, NCF: nanocellulose fiber, SA: sodium alginate, PEI: polyethyleneimine]) was prepared through environmentally friendly methods. The La-NCF/SA-PEI hydrogel, featuring a 3D porous structure with interwoven functional groups (amino, quaternary ammonium, and lanthanum), demonstrated a maximum P adsorption capacity of 78.
View Article and Find Full Text PDFA novel multifunctional PEEK internal fixation plate regulated by Gentamicin/chitosan coating.
Colloids Surf B Biointerfaces
January 2025
Research Center of Biomass 3D Printing Materials, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China; Department of Pharmacy Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Polyetheretherketone (PEEK) has been broadly used in orthopedic implant devices. Nevertheless, the bioinert tended to cause implant loosening and bacterial infection in orthopedic and trauma surgery. In this study, a drug-laden chitosan coating (CS) was constructed and deposited on the porous surface of PEEK (CG-SPEEK) internal fixation plate for multi-functionalization.
View Article and Find Full Text PDFActivating Metal-Organic Cages by Incorporating Functional M(ImPhen) Metalloligands: From Structural Design to Applications.
Acc Chem Res
November 2024
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, GBRCE for Functional Molecular Engineering, LIFM, IGCME, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Article Synopsis
- Researchers have focused on mimicking natural biofunctions through the development of metal-organic cages (MOCs), which are structured assemblies designed to replicate properties of enzymes and protein cages.* -
- The key to achieving specific functionalities in these cages involves designing their structures to create confined environments that support specialized reactivities and selectivities, making them useful in areas like molecular transport and catalysis.* -
- This work emphasizes the use of M(ImPhen) metalloligands to build multifunctional MOCs, allowing for the customization of properties by pairing various metal ions with their unique characteristics for enhanced stability and performance in biological applications.*
Fabrication and characterization of dual-functional porous starch with both emulsification and antioxidant properties.
Int J Biol Macromol
April 2024
College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, Gansu, China; State Key Laboratory of Arid Land Crop Science, Gansu Agricultural University, Lanzhou 730070, Gansu, China. Electronic address:
Starchy materials with good antioxidant, emulsification and adsorption properties have potential applications in industry. To improve these properties, a Dual-functional porous starch was prepared through one-pot synthesis. In this case, octenyl succinic anhydride (OSA) and syringic acid (SA) were selected to modify the porous starch (PS) by esterification, with subsequent signals recorded by H NMR at 1.
View Article and Find Full Text PDFProtein-activated atomic layer deposition for robust crude-oil-repellent hierarchical nano-armored membranes.
Sci Bull (Beijing)
January 2024
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China. Electronic address:
Atomic layer deposition (ALD) offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water systems. However, current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation sites. Here, we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/sensitization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!