AI Article Synopsis
- Biomaterials can be improved to create effective and universal solutions for bone regeneration, focusing on the use of conductive carbon nanotube (CNT)-based materials.
- Research involved applying biphasic electrical stimulation to human osteoblastic cells using both bioactive bone grafts and conductive CNT composites to assess their effects on cellular functions.
- Results indicated that conductive substrates enhanced the delivery of electrical stimuli, leading to increased bone cell proliferation and improved gene expression, demonstrating their potential for precise control in bone regeneration processes.
Article Abstract
Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, conductive CNT-based "smart" materials accumulate exciting grafting qualities for tuning the in vitro cellular phenotype. Biphasic electrical stimulation of human osteoblastic cells was performed in vitro on either dielectric bioactive bone grafts or conductive CNT-reinforced composites. The efficiency of the electrical stimuli delivery, as well as the effect of stimulation on cellular functions were investigated. Conductive substrates boosted the local culture medium conductivity and the confinement of the exogenous electrical fields. Hence, bone cell proliferation, DNA content and mRNA expression were maximized on the conductive substrates yielding superior stimuli delivering efficiency over dielectric ones. These findings are suggestive that bioactive bone grafts with electrical conductivity are capable of high spatial and temporal control of bone cell stimulation.
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| http://dx.doi.org/10.1039/c4tb01628a | DOI Listing |
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