AI Article Synopsis
- The study introduces a multifunctional biocompatible nanoplatform made from a biodegradable PLGA matrix, enhanced with indocyanine green (ICG) for imaging, and loaded with superparamagnetic iron oxide nanoparticles (SPIONs) and the chemotherapy drug doxorubicin (DOXO).
- The nanoplatform demonstrated effective cancer treatment capabilities through a combination of chemotherapy and photothermal therapy, and it successfully allowed for magnetic targeting and imaging in cervical cancer cells and in vivo in a mouse model.
- Notably, the nanoplatform showed significant tumor accumulation and unexpected distribution in the brain, suggesting potential for bypassing the blood-brain barrier and paving the way for treating brain-related diseases.
Article Abstract
We report the synthesis of a multifunctional biocompatible theranostic nanoplatform consisting of a biodegradable PLGA matrix surface-functionalized with indocyanine green (ICG), a near-IR fluorescent dye, and co-loaded with superparamagnetic iron oxide nanoparticles (SPIONs) and the anticancer drug doxorubicin (DOXO). Combination of chemo- and photothermal therapeutic efficacy as well as magnetic resonance and optical fluorescence imaging performance were successfully tested in vitro on a tumoral cervical HeLa cell line. Magnetic in vitro guided targeting of these nanoplatforms was also proven. These nanoconstructs also enabled to monitor their in vivo biodistribution by fluorescence imaging in a mice model, which revealed their effective accumulation in the tumor and, unexpectedly, in the brain area. A lower presence of nanoplatforms was noted in the reticulo-endothelial system. The present observations suggest the nanoplatforms ability to possibly overcome the blood brain barrier. These results open up new possibilities to use our multifunctional nanoplatforms to treat brain-located diseases.
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| http://dx.doi.org/10.1039/c4tb01273a | DOI Listing |
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